PD 156273 is a potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor. PD 156273 also inhibits the primary human tumor cell cultures growth.
1. Bridges, A J., et al., 1996. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. Journal of medicinal chemistry. 39(1): 267-76. PMID: 8568816
2. Baguley, B C., et al., 1998. Inhibition of growth of primary human tumour cell cultures by a 4-anilinoquinazoline inhibitor of the epidermal growth factor receptor family of tyrosine kinases. European journal of cancer (Oxford, England : 1990). 34(7): 1086-90. PMID: 9849459
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