PD 153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of the EGFR (epidermal growth factor receptor; IC50 = 25 pM; Kι = 6 pM). PD 153035 rapidly suppresses auto-phosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. PD 153035 also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation.
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See how others have used PD 153035. Click on the entry to view the PubMed entry .
PMID: # 28797129 Go, YY. et al. 2017. PLoS ONE. 12: e0182716.
PMID: # 27086143 Centuori, SM. et al. 2016. Biochim. Biophys. Acta. 1861: 663-70.
PMID: # 24982815 Zhu, HJ. et al. 2014. Am J Nucl Med Mol Imaging. 4: 293-302.
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