PD 123319 ditrifluoroacetateCAS: 130663-39-7
MF: C31H32N4O3•2CF3CO2H
MW: 736.67
A selective non-peptide angiotensin AT2 receptor antagonist.

PD 123319 ditrifluoroacetate (CAS 130663-39-7)

PD 123319 ditrifluoroacetate | CAS 130663-39-7 is rated 5.0 out of 5 by 1.
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Application: A selective non-peptide angiotensin AT2 receptor antagonist
CAS Number: 130663-39-7
Purity: ≥99%
Molecular Weight: 736.67
Molecular Formula: C31H32N4O32CF3CO2H
* Refer to Certificate of Analysis for lot specific data (including water content).
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PD 123319 ditrifluoroacetate is a potent, selective non-peptide angiotensin AT2 receptor antagonist. Tested on rat adrenal tissue and brain. This compound prevents the binding of angiotensin II to the receptor, which blocks signal transduction and causes vasodilation.


References

1. Blankley, C.J., et al. 1991. J. Med. Chem. 34: 3248-3260. PMID: 1956044
2. Boulay, G., et al. 1992. Mol. Pharmacol. 41: 809-815. PMID: 1569928
3. Tamura, M., et al. 2000. J. Hypertens. 18: 1239-1246. PMID: 10994755
4. Shimada, K. et al. 2015. J. Cereb. Blood Flow Metab. 35(7): 1163-1168. PMID: 25757758

Usage :
Highly hygroscopic
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Desiccate at 4° C
Boiling Point :
775.8° C at 760 mmHg (Predicted)
Optical Activity :
α20/D +8.6°, c = 0.87 in methanol
IC50 :
AT2 receptor: IC50 = 34 nM (rat adrenal); AT2 receptor: IC50 = 210 nM (rat brain)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6604951
SMILES :
CC1=C(C=CC(=C1)CN2C=NC3=C2C[[email protected]](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

Download SDS (MSDS)

Certificate of Analysis

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PD 123319 ditrifluoroacetate  Product Citations

See how others have used PD 123319 ditrifluoroacetate. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28722118  Liao, MC. et al. 2017. J. Pathol.

PMID: # 27658784  Liu, X. et al. 2016. Apoptosis. 21: 1315-1326.

PMID: # 27630693  Ma, CY. et al. 2016. Neural Regen Res. 11: 1102-7.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Shimada Shimada, K. et al. (PubMed 25757758) used PD 123319, a potent and selective non-peptide angiotensin AT2 receptor antagonist, to determine that Angiotensin-(1-7) can protect against the development of aneurysmal rupture in an AT2R-dependent manner. -SCBT Publication Review
Date published: 2015-07-17
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