PD 102807 CAS: 23062-91-1
MF: C23H24N2O4
MW: 392.45
A selective mAChR M4 antagonist.

PD 102807 (CAS 23062-91-1)

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Alternate Names: 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester
Application: PD 102807 is a selective mAChR M4 antagonist
CAS Number: 23062-91-1
Purity: ≥98%
Molecular Weight: 392.45
Molecular Formula: C23H24N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).
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PD 102807 is a selective mAChR M4 antagonist with IC50 values are 91, 6559, 3441, 950 and 7412 nM for human mAChR M4, mAChR M1, mAChR M2, mAChR M3, and mAChR M5 receptors, respectively.


References

1. Augelli-Szafran, C.E., et al. 1998. Bioorg. Med. Chem. Lett. 8: 1991-1996.
2. Kitaichi, K., et al. 1999. Eur. J. Pharmacol. 383: 53-56.
3. Bohme, T.M., et al. 2002. J. Med. Chem. 45: 3094-3102.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
227.40° C (Predicted)
Boiling Point :
586.0° C at 760 mmHg (Predicted)
Density :
1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
mAChR M4: IC50 = 91 nM (human); mAChR M3: IC50 = 950 nM (human); mAChR M2: IC50 = 3.44 µM (human); mAChR M1: IC50 = 6.56 µM (human); mAChR M5: IC50 = 7.41 µM (human)
pK Values :
pKb: 4.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
PubChem CID :
MDL Number :
MFCD04118313
SMILES :
CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C

Download SDS (MSDS)

Certificate of Analysis

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