PCO 400An analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener

PCO 400 (CAS 121055-10-5)

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Synonym: PCO-400
Application: An analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener
CAS Number: 121055-10-5
Molecular Weight: 299.32
Molecular Formula: C17H17NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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PCO 400 is an analog of comakalim and a selective and potent ATP-sensitive K+ channel opener. It has been shown to evoke relaxation of isolated airway smooth muscle in a dose-dependent manner. Upon intravenous injection, transient inhibition of histamine-induced bronchospasm was effected. Inhaled as a dry powder, it can suppress the development of allergic airway hyperreactivity to histamine.


References

1. Robertson, D.W., et al. 1990. J. Med. Chem. 33: 1529-1541. PMID: 2187993
2. Edwards, G., et al. 1990. Trends Pharmacol. Sci. 11: 417-422. PMID: 2256183
3. Chapman, I.D., et al. 1992. Br. J. Pharmacol. 106: 423-429. PMID: 1382782

Physical State :
Solid
Solubility :
Soluble in ethanol (30 mg/ml), and DMSO (>200 mg/ml).
Storage :
Store at room temperature
Melting Point :
154-156° C
Boiling Point :
496.7° C at 760 mmHg (Predicted)
Density :
1.32 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
airway smooth muscle: IC50 = 1.8 µM (human or guinea pig)
pK Values :
pKa: 13.09
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
129348
MDL Number :
MFCD00879250
SMILES :
CC1([C@H]([C@@H](C2=C(O1)C=CC(=C2)C#N)OC3=CC(=O)CC3)O)C

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Certificate of Analysis

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