Pazopanib HydrochlorideA multi-targeted inhibitor

Pazopanib Hydrochloride (CAS 635702-64-6)

Pazopanib Hydrochloride | CAS 635702-64-6 is rated 5.0 out of 5 by 1.
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Synonym: Votrient; Armala
Application: A multi-targeted inhibitor
CAS Number: 635702-64-6
Purity: ≥98%
Molecular Weight: 473.98
Molecular Formula: C21H23N7O2S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel, multitargeted inhibitor of flt-1(VEGFR-1), Flk-1(VEGFR-2), flt-4 (VEGFR-3), PDGFR, FGFR, c-Kit and c-Fms-CSF-1R (c-fms) with IC50 values of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (17 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 30% PEG400/0.5% Tween80/5% propylene glycol (30 mg/ml at 25 °C).
Storage :
Store at -20° C
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
Flk-1: IC50 = 5.01 nM (human); Flt-1: IC50 = 10 nM (human); Flt-4: IC50 = 47 nM (human); c-Kit: IC50 = 74 nM (human); PDGFR-β: IC50 = 84 nM (human)
Ki Data :
Flk-1: Ki= 3.16 nM (human); PDGFR-β: Ki= 3.98 nM (human); Flt-1: Ki= 15.85 nM (human); c-Fms/CSF-1R: Ki= 19.95 nM (human); Ret: Ki= 79.43 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11525740
MDL Number :
MFCD12546138
SMILES :
CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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Pazopanib Hydrochloride  Product Citations

See how others have used Pazopanib Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25470057  Oehlers, S.H. et al. 2015. Nature. 517: 612-5.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Takahashi K; et al Takahashi K; et al. (PubMed ID: 19365030) determined that Pazopanib Hydrochloride, a multitargeted kinase inhibitor, strongly inhibits choroidal neovascularization in mice. -SCBT Publication Review
Date published: 2015-04-03
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