PaxillineA selective and reversible calcium-activated potassium channel blocker

Paxilline (CAS 57186-25-1)

Paxilline | CAS 57186-25-1 is rated 5.0 out of 5 by 1.
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Application: A selective and reversible calcium-activated potassium channel blocker
CAS Number: 57186-25-1
Purity: ≥97%
Molecular Weight: 435.55
Molecular Formula: C27H33NO4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Paxilline is an indole alkaloid isolated from Penicillium paxilli. Paxilline has been shown to selectively and reversibly block the high conductance Ca2+-activated K+ channel. In neutrophils, Paxilline blockage of Maxi-K channels decreased the alkalinization of phagocytic vacuoles and inhibited the microbicidal process. When paxilline was applied to the smooth muscle of the rat vas deferens at more positive potentials than -40 mV up to 15 mV, significant depolarization of the smooth muscle contractions was observed. Paxilline is an inhibitor of MaxiKα, IP3R and SERCA.


References

1. Cole, R.J., et al. 1974. Can. J. Microbiol. 20: 1159-1162. PMID: 4425383
2. Vázquez, J., et al. 1990. J. Biol. Chem. 265: 15564-15571. PMID: 1697593
3. Knaus, H.G., et al. 1994. Biochemistry. 33: 5819-5828. PMID: 7514038
4. Strøbaek, D., et al. 1996. Neuropharmacology. 35: 903-914. PMID: 8938721
5. Sanchez, M. and McManus, O.B. 1996. Neuropharmacology. 35: 963-968. PMID: 8938726
6. Young, C., et al. 1998. Curr. Genet. 33: 368-377. PMID: 9618588
7. Longland, C.L., et al. 2000. Eur. J. Pharmacol. 408: 219-225. PMID: 11090637
8. Femling, J.K., et al. 2006. J. Gen. Physiol. 127: 659-672. PMID: 16702353
9. Kryshtal', D.O., et al. 2007. Fiziol Zh. 53: 67-74. PMID: 18080495

Physical State :
Solid
Derived From :
Penicillium paxilli
Solubility :
Soluble in DMSO (50 mg/ml), acetone (5 mg/ml), and chloroform (10 mg/ml).
Storage :
Store at -20° C
Melting Point :
252° C
Boiling Point :
648.8° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DJ2830000
PubChem CID :
4697
MDL Number :
MFCD00083464
SMILES :
CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O

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Paxilline  Product Citations

See how others have used Paxilline. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 26426046  Maragos, CM. et al. 2015. Toxins (Basel). 7: 3903-15.

PMID: # 23345219  Cuddapah, VA. et al. 2013. J. Neurosci. 33: 1427-1440.

PMID: # 22992678  McFerrin, MB. et al. 2012. Am. J. Physiol., Cell Physiol. 303: C1070-8.

PMID: # 22049206  Cuddapah, VA. et al. 2012. Am. J. Physiol., Cell Physiol. 302: C527-38.

PMID: # 20139089  Cuddapah, VA. et al. 2010. J. Biol. Chem. 285: 11188-96.

PMID: # 19052171  Kim, EY. et al. 2009. Mol. Pharmacol. 75: 466-477.

PMID: # 19778436  Wondergem, R. et al. 2009. J. Biomed. Sci. 16: -.

PMID: # 18480178  Kim, EY. et al. 2008. Am. J. Physiol. Renal Physiol. 295: F235-F246.

PMID: # 17519950  Yeung, SY. et al. 2007. Br. J. Pharmacol. 151: 758-770.

PMID: # 16857962  Seubert, JM. et al. 2006. Circ. Res. 99: 442-450.

Citations 1 to 10 of 14 total
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Rated 5 out of 5 by from Wondergem Wondergem, et. al. (PubMed ID 19778436) was able to stop the increase of intracellular calcium caused by exposure to Menthol by treating the DBTRG cells with paxilline during whole-cell voltage clamp experiments. -SCBT Publication Review
Date published: 2015-03-21
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