ParthenolideAn inhibitor specifically inhibits HDAC1 without affecting other class I/II HDACs

Parthenolide (CAS 20554-84-1)

Parthenolide | CAS 20554-84-1 is rated 4.5 out of 5 by 2.
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Application: An inhibitor specifically inhibits HDAC1 without affecting other class I/II HDACs
CAS Number: 20554-84-1
Purity: ≥99%
Molecular Weight: 248.3
Molecular Formula: C15H20O3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. Parthenolide is a sesquiterpene lactone, a class of naturally occurring plant terpenoids, and an active principle of feverfew (Chrysanthemum parthenium). Parthenolide has demonstrated anti-inflammatory, antisecretory and spasmolytic activity. Parthenolide has been shown to inhibit the release of various chemical mediators such as Cox-2, TNF-α and IL-1 in LPS-stimulated macrophages and activation of MAP kinase and NFκβ. Recent findings indicate that parthenolide binds to and directly inhibits Iκβ kinase. The compound has also been shown to block the production of thromboxane B2 and leukotriene B4.


References

1. Groenewegen, W.A., et al. 1990. J. Pharm. Pharmacol. 42: 553-557. PMID: 1981582
2. Sumner, H., et al. 1992. Biochem. Pharmacol. 43: 2313-2320. PMID: 1319159
3. Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44 :737-740. PMID: 1360525
4. Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226: 810-818. PMID: 8831694
5. Hehner, S.P., et al. 1999. J. Immunol. 163: 5617-5623. PMID: 1055309
6. Kwok, B.H., et al. 2001. Chem. Biol. 8: 759-766. PMID: 11514225

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), ethanol (20 mg/ml), and water (partly miscible).
Storage :
Store at -20° C
Melting Point :
115-116° C
Boiling Point :
394.10° C at 760 mmHg (Predicted)
Density :
1.13 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LY4220000
PubChem CID :
7251185
Merck Index :
14: 7048
MDL Number :
MFCD00134592
Beilstein Registry :
3550011
SMILES :
C/C/1=C\\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C

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Certificate of Analysis

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Parthenolide  Product Citations

See how others have used Parthenolide. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 20 total

PMID: # 29681981  Yim, MJ. et al. 2018. Evid Based Complement Alternat Med. 2018: 6914514.

PMID: # 29273374  Ren, H.|Meng, Q.|Yepuri, N.|Du, X.|Sarpong, JO.|Cooney, RN.| et al. 2018. J. Surg. Res. 222: 39-47.

PMID: # 26179215  Tarapore, RS. et al. 2016. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 31: 52-64.

PMID: # 26136104  Paeng, SH. et al. 2015. International journal of molecular medicine. 36: 808-16.

PMID: # 25826425  Doerner, JL. et al. 2015. The Journal of investigative dermatology. 135: 1986-95.

PMID: # 26378023  Zhang, YC. et al. 2015. Oncotarget. 6: 33554-67.

PMID: # 25955241  Park, H. et al. 2015. International journal of molecular medicine. 36: 301-8.

PMID: # 26305961  Hu, C. et al. 2015. Proceedings of the National Academy of Sciences of the United States of America. 112: 11318-23.

PMID: # 21903858  Bommarito, A. et al. 2011. Endocr. Relat. Cancer. 18: 669-685.

PMID: # 20718930  Kulikova, L. et al. 2010 Nov-Dec. Photochem. Photobiol. 86: 1285-1293.

Citations 1 to 10 of 20 total

You know that Parthenolide is not soluble in water, therefore it is not well adsorbed. What are you doing for better absorption?

Asked by: Judith
Thank you for your question. Parthenolide (CAS 20554-84-1) is soluble in DMSO (100 mg/ml), ethanol (20 mg/ml), and water (partly miscible). We have not used this chemical directly in any research applications. Additional references are provided below that may be helpful in answering your question. 1. Groenewegen, W.A., et al. 1990. J. Pharm. Pharmacol. 42: 553-557. PMID: 1981582 2. Sumner, H., et al. 1992. Biochem. Pharmacol. 43: 2313-2320. PMID: 1319159 3. Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44 :737-740. PMID: 1360525 4. Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226: 810-818. PMID: 8831694 5. Hehner, S.P., et al. 1999. J. Immunol. 163: 5617-5623. PMID: 1055309 6. Kwok, B.H., et al. 2001. Chem. Biol. 8: 759-766. PMID: 11514225
Answered by: Technical Support
Date published: 2017-03-01
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Rated 5 out of 5 by from deGraffenried deGraffenried, et. al. (PubMed ID 15151944) found that along with overexpression of IkB superrepressor and treatment with a NF-kB inhibitor, Parthenolide (purchased from SCBT) restored tamoxifen sensitivity to their refractory Akt MCF-7 cells. -SCBT Publication Review
Date published: 2015-04-20
Rated 4 out of 5 by from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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