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PARP Inhibitor XI, DR2313 is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor. PARP (Poly(ADP-ribose) polymerase) function by triggering DNA repair mechanisms and activating apoptosis in damaged cells. Studies show that DR2313 competes with NAD+ but does not display selectivity among PARP-1 and PARP-2. In addition, in vitro studies of cerebral ischemia exhibiting an overactivation of PARP show that ischemic damage can be reduced by introducing DR2313.
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