PARP Inhibitor XI, DR2313A competitive and water soluble PARP inhibitor

PARP Inhibitor XI, DR2313 (CAS 284028-90-6)

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Application: A competitive and water soluble PARP inhibitor
CAS Number: 284028-90-6
Molecular Weight: 182.2
Molecular Formula: C8H10N2OS
* Refer to Certificate of Analysis for lot specific data (including water content).
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PARP Inhibitor XI, DR2313 is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor. PARP (Poly(ADP-ribose) polymerase) function by triggering DNA repair mechanisms and activating apoptosis in damaged cells. Studies show that DR2313 competes with NAD+ but does not display selectivity among PARP-1 and PARP-2. In addition, in vitro studies of cerebral ischemia exhibiting an overactivation of PARP show that ischemic damage can be reduced by introducing DR2313.


References

1. Nakajima, H., et al. 2005. J. Pharmacol. Exp. Ther. 312: 472-481. PMID: 15466246
2. Lehtiö, L., et al. 2009. J. Med. Chem. 52: 3108-3111. PMID: 19354255

Physical State :
Solid
Solubility :
H2O
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10219702
SMILES :
CC1=NC(=O)C2=C(N1)CCSC2

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Certificate of Analysis

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