PARP Inhibitor VIII, PJ34CAS: 344458-15-7
MF: C17H17N3O2•HCl
MW: 331.80
A potent and cell-permeable inhibitor of PARP.

PARP Inhibitor VIII, PJ34 (CAS 344458-15-7)

PARP Inhibitor VIII, PJ34 | CAS 344458-15-7 is rated 5.0 out of 5 by 1.
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Synonym: PJ-34; 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride
Application: A potent and cell-permeable inhibitor of PARP
CAS Number: 344458-15-7
Purity: ≥98%
Molecular Weight: 331.80
Molecular Formula: C17H17N3O2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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PARP Inhibitor VIII, PJ34 is a cell-permeable, water-soluble phenanthridinone derivative which inhibits of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). It is believed to be up to 10,000 times more potent than 3-aminobenzamide (sc-3501) which has an EC = 200 μM. Studies have shown that PARP over-activation can lead to NAD depletion and consequent necrosis, thus inducing inflammatory conditions in many diseases. It has been observed that at lower concentrations, PARP Inhibitor VIII, PJ34 displays antioxidant activity. Studies conducted in vitro on stroke models indicate that this compound has neuroprotective functions. PARP Inhibitor VIII, PJ34 is an inhibitor of PARP-1 and PARP-2.


References

Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (22 mg/ml), and DMSO (100 mM).
Storage :
Store at -20° C
IC50 :
PARP: EC5050 = 20 nM; peroxynitrite-induced cell necrosis: EC5050 = 20 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760621
SMILES :
CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl

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Certificate of Analysis

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PARP Inhibitor VIII, PJ34  Product Citations

See how others have used PARP Inhibitor VIII, PJ34. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 31303961  2019. Oncotarget. 10: 4262-4275.

PMID: # 29143372  Alawieyah Syed Mortadza, S.|Sim, JA.|Neubrand, VE.|Jiang, LH.| et al. 2018. Glia. 66: 562-575.

PMID: # 30387075  Prado Spalm, FH. et al. 2018. Mol. Neurobiol.

PMID: # 28322340  Mortadza, SS.|Sim, JA.|Stacey, M.|Jiang, LH.| et al. 2017. Sci Rep. 7: 45032.

PMID: # 27171262  Huh, MS. et al. 2016. Cell death & disease. 7: e2220.

PMID: # 27302486  2016. Cell. Microbiol.

PMID: # 24223135  Jagirdar, K. et al. 2013. PloS one. 8: e78075.

PMID: # 21979916  Malewicz, M. et al. 2011. Genes Dev. 25: 2031-40.

PMID: # 21786338  Hanssen-Bauer, A. et al. 2011. Environmental and molecular mutagenesis. 52: 623-35.

Citations 1 to 9 of 9 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. PARP Inhibitor VIII, PJ34, sc-204161, is a light grey powder.
Answered by: Chemical Support 4
Date published: 2017-03-14
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Rated 5 out of 5 by from Liang Liang, BY. et al. (PubMed 26223923) found a synergistic suppressive effect of PARP-1 inhibitor PJ34 and HDAC inhibitor SAHA (sc-220139) on proliferation of liver cancer cells. -SCBT Publication Review
Date published: 2015-06-14
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