PARP Inhibitor IX, EB-47An isoindolinone compound that inhibits PARP-1

PARP Inhibitor IX, EB-47 (CAS 366454-36-6)

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Application: An isoindolinone compound that inhibits PARP-1
CAS Number: 366454-36-6
Purity: ≥95%
Molecular Weight: 646.5
Molecular Formula: C24H27N9O6 2HCl 2H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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PARP Inhibitor IX, EB-47 is a cell-permeable, adenosine-substituted, isoindolinone compound that acts as a strong inhibitor of PARP-1. PARP Inhibitor IX, EB-47 has been shown to offer cytoprotective effects against oxidative damage in cells and in models of reperfusion injury and inflammation.


References

Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml).
Storage :
Store at -20° C
Boiling Point :
1142.8° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.87 (Predicted)
IC50 :
PARP-1 : IC50 = 45 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760406
SMILES :
C1CN(CCN1CC(=O)NC2=CC=CC3=C2CNC3=O)C(=O)C4[C@@H]([C@@H]([C@H](O4)N5C=NC6=C5N=CN=C6N)O)O.O.O.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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