Paroxetine HClA highly potent and selective serotonin (5-HT) uptake inhibitor

Paroxetine HCl (CAS 78246-49-8)

Paroxetine HCl | CAS 78246-49-8 is rated 5.0 out of 5 by 1.
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Synonym: Paroxat
Application: A highly potent and selective serotonin (5-HT) uptake inhibitor
CAS Number: 78246-49-8
Purity: ≥98%
Molecular Weight: 365.82
Molecular Formula: C19H20FNO3•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Paroxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6).


References

1. Thomas, D.R., et al. 1987. Psychopharmacology. 93: 193-200. PMID: 2962217
2. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006
3. Bourin, M., et al. 2001. CNS Drug Rev. 7: 25-47. PMID: 11420571
4. Fujishiro, J., et al. 2002. Eur. J. Pharmacol. 454: 183-188. PMID: 12421645

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), chloroform, and methanol. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
137-139° C
Ki Data :
serotonin transporter : Ki= 0.05 nM; muscarinic Ach receptors: Ki= 42 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
TM4569300
PubChem CID :
62878
Merck Index :
14: 7043
SMILES :
C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl

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Paroxetine HCl  Product Citations

See how others have used Paroxetine HCl. Click on the entry to view the PubMed entry .

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PMID: # 27288589  Saroja, SR.|Aher, YD.|Kalaba, P.|Aher, NY.|Zehl, M.|Korz, V.|Subramaniyan, S.|Miklosi, AG.|Zanon, L.|Neuhaus, W.|Höger, H.|Langer, T.|Urban, E.|Leban, J.|Lubec, G.| et al. 2016. Behav. Brain Res. 312: 127-37.

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Rated 5 out of 5 by from Fujishiro et al Fujishiro et al. (PubMed ID 12421645) found that paroxetine inhibited serotonin reuptake and exhibited anticholinergic effects that led to the reduction of oxotremorine-induced tremor. -SCBT Publication Review
Date published: 2015-01-15
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