Paroxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6).
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See how others have used Paroxetine HCl. Click on the entry to view the PubMed entry .
PMID: # 27288589 Saroja, SR.|Aher, YD.|Kalaba, P.|Aher, NY.|Zehl, M.|Korz, V.|Subramaniyan, S.|Miklosi, AG.|Zanon, L.|Neuhaus, W.|Höger, H.|Langer, T.|Urban, E.|Leban, J.|Lubec, G.| et al. 2016. Behav. Brain Res. 312: 127-37.
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