Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.
1. Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle. Robertson A.P. et al. J. Pharmacol. Exp. Ther. 2002, 302, 853. 2. Novel antinematodal and antiparasitic agents from Penicillium charlesii I. Fermentation, isolation and biological activity. Ondeyka J.G. J. Antibiot. 1990, 43, 1375. 3. The structure of parherquamide, a toxic metabolite from Penicillium paraherquei. Yamazaki M.E. et al. Tetrahedron Lett. 1982, 22, 135.