Paraherquamide A CAS: 77392-58-6
MF: C28H35N3O5
MW: 493.6
A selective, competitive, cholinergic antagonist.

Paraherquamide A (CAS 77392-58-6)

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Alternate Names: Paraherquamide
Application: Paraherquamide A is a selective, competitive, cholinergic antagonist
CAS Number: 77392-58-6
Purity: >95%
Molecular Weight: 493.6
Molecular Formula: C28H35N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.


References

1. Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle. Robertson A.P. et al. J. Pharmacol. Exp. Ther. 2002, 302, 853. 2. Novel antinematodal and antiparasitic agents from Penicillium charlesii I. Fermentation, isolation and biological activity. Ondeyka J.G. J. Antibiot. 1990, 43, 1375. 3. The structure of parherquamide, a toxic metabolite from Penicillium paraherquei. Yamazaki M.E. et al. Tetrahedron Lett. 1982, 22, 135.

Appearance :
Powder
Physical State :
Solid
Derived From :
Penicillium simplicissimum
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and water (poorly).
Storage :
Store at -20° C
Melting Point :
290.08° C (Predicted)
Boiling Point :
682.78° C at 760 mmHg (Predicted)
Density :
1.39 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
RV0545000
PubChem CID :
MDL Number :
MFCD01709427
Beilstein Registry :
3599562
SMILES :
CC1(C=COC2=C(O1)C=CC3=C2NC(=O)C34CC56CN7CCC(C7(CC5C4(C)C)C(=O)N6C)(C)O)C

Download SDS (MSDS)

Certificate of Analysis

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