Papaverine hydrochlorideAn alkaloid that may inhibit phosphodiesterases and/or calcium channel actions

Papaverine hydrochloride (CAS 61-25-6)

Papaverine hydrochloride | CAS 61-25-6 is rated 5.0 out of 5 by 1.
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Synonym: 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride
Application: An alkaloid that may inhibit phosphodiesterases and/or calcium channel actions
CAS Number: 61-25-6
Purity: ≥98%
Molecular Weight: 375.85
Molecular Formula: C20H21NO4·HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Papaverine hydrochloride is an alkaloid originally isolated from opium bearing little relation to other opium alkaloids in structure or pharmacological actions. Experiments indicate smooth muscle relaxant activity, with noted treatment for impotence. It can also act as a cerebral vasodilator through the possible inhibition of PDE (phosphodiesterases) and/or calcium channel actions.


References

1. Pöch, G., et al. 1971. Life Sci I. 10: 133-144. PMID: 4325052
2. Ferrari, M., et al. 1974. Pharmacol Res Commun. 6: 97-115. PMID: 4373766
3. Han, D.H., et al. 2007. Neurol. Res. 29: 544-550. PMID: 17535590

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), DMSO, methanol, 100% ethanol, and chloroform.
Storage :
Store at 4° C
Melting Point :
226° C
Boiling Point :
483.2° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
PDE10A: IC50 = 17 nM (human); cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A: IC50 = 36 nM (rat); PDE3A: IC50 = 284 nM (human); Phosphodiesterase 3A: IC50 = 620 nM (pig); CYP2C19: IC50 = 762 nM (human)
Ki Data :
PDE3A: Ki= 279 nM (human); PDE3B: Ki= 417 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
NW8575000
PubChem CID :
6084
Merck Index :
14: 7019
MDL Number :
MFCD00012745
EC Number :
200-502-1
Beilstein Registry :
3921435
SMILES :
COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC.Cl

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Certificate of Analysis

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Papaverine hydrochloride  Product Citations

See how others have used Papaverine hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 26205238  Corradini, E. et al. 2015. Mol Biosyst. 11: 2786-97.

PMID: # 17535590  Han, DH. et al. 2007. Neurol. Res. 29: 544-550.

PMID: # 4373766  Ferrari, M. et al. 1974. Pharmacol Res Commun. 6: 97-115.

PMID: # 4325052  Pöch, G. et al. 1971. Life Sci I. 10: 133-144.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Han Han, DH. et al. (PubMed 17535590) investigated the effect of Papaverine on ion channels in rat basilar smooth muscle cells. Their results strongly suggest that Ca(2+)-activated potassium channels and L type Ca(2+) channels may be involved in Papaverine-induced vascular relaxation in rat basilar artery. -SCBT Publication Review
Date published: 2015-03-21
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