Pamidronate, Disodium SaltA calcium metabolism regulator

Pamidronate, Disodium Salt (CAS 109552-15-0)

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Application: A calcium metabolism regulator
CAS Number: 109552-15-0
Purity: ≥95%
Molecular Weight: 369.1
Molecular Formula: C3H9NO7P2·2Na•5H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pamidronate, Disodium Salt is a bisphosphonate calcium metabolism regulator which specifically induces calcium reabsorption in bones. In addition, Pamidronate selectively activates γδTcells in peripheral blood mononuclear cells. Alternate studies indicate that Pamidronate, Disodium Salt promotes osteoblast proliferation and differentiation while inhibiting osteoclastogenesis and osteoclast function. Furthermore, Pamidronate down-regulates urokinase-type plasminogen activator expression by suppressing uPA mRNA in PC-3 cells. Pamidronate, Disodium Salt is an inhibitor of FDPS (farnesyl diphosphate synthase).


1. Kunzmann, V., et al. 1999. N. Engl. J. Med. 340: 737-738. PMID: 10068336
2. Iguchi, K., et al. 2007. Anticancer Res. 27: 3843-3848. PMID: 18225541
3. Panzavolta, S., et al. 2009. J. Inorg. Biochem. 103: 101-106. PMID: 18977031

Physical State :
Solubility :
Soluble in water (28 mg/ml).
Storage :
Store at -20° C
Boiling Point :
658.7° C at 760 mmHg (Predicted)
pK Values :
pKa: 1.44 (Predicted), pKb: 8.93 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
Merck Index :
14: 7003
MDL Number :

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Certificate of Analysis

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