p53 Activator III, RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis. Renal carcinoma research has demonstrated that RITA induces DNA damage, and DNA-DNA, DNA-protein crosslinks. Furthermore, low concentrations of RITA caused cell cycle arrest in G0-G1 and G2-M, and elevated p53 and p21(WAF1) protein levels in renal carcinoma studies. At higher concentrations RITA has been reported to cause an increases of p53 protein levels, reduces p21(WAF1) protein levels, and induce apoptosis.
1. Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57: 1283-1295. PMID: 10230772
2. Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56: 478-484. PMID: 10462535
3. Issaeva, N., et al. 2004. Nat. Med. 10: 1321-1328. PMID: 15558054
See how others have used p53 Activator III, RITA. Click on the entry to view the PubMed entry .
PMID: # 30447254 Azatyan, A.|Gallo-Oller, G.|Diao, Y.|Selivanova, G.|Johnsen, JI.|Zaphiropoulos, PG.| et al. 2019. Cancer Lett. 442: 341-350.
PMID: # 28608259 Qiu, M. et al. 2017. Cancer Chemother. Pharmacol. 80: 275-286.
PMID: # 22166212 Ma, T. et al. 2012. Biochem. Biophys. Res. Commun. 417: 931-7.
PMID: # 15558054 Issaeva, N. et al. 2004. Nature Medicine. 10: 1321-1327.
PMID: # 10230772 Rivera, MI. et al. 1999. Biochem. Pharmacol. 57: 1283-1295.
PMID: # 10462535 Nieves-Neira, W. et al. 1999. Mol. Pharmacol. 56: 478-484.
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