p21 Waf1/Cip1/CDKN1A CRISPR Plasmids (h) human p21 Waf1/Cip1/CDKN1A-specific CRISPR/Cas9 KO Plasmid, HDR Plasmid, Double Nickase Plasmids, CRISPR Activation Plasmids and Lentiviral Activation Particles

p21 Waf1/Cip1/CDKN1A CRISPR Plasmids (h)

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    • Target species: human; for corresponding mouse product, see p21 Waf1/Cip1/CDKN1A CRISPR Plasmids (m)
    • CRISPR/Cas9 KO Plasmids consists of p21 Waf1/Cip1/CDKN1A-specific 20 nt guide RNA sequences derived from the GeCKO (v2) library
    • For CRISPR gene knockout, gRNA sequences direct the Cas9 protein to induce a site-specific double strand break (DSB) in the genomic DNA
    • Target-specific CRISPR Plasmids for both gene knockout and activation are available. Please refer to the detailed product information in the tabs below
    • Gene knockdown or activation can be assayed using p21 Waf1/Cip1/CDKN1A Antibody (F-5): sc-6246
    • All products are provided as transfection-ready, purified plasmid DNA, except the Lentiviral Activation Particles which have been prepackaged as Lentiviral Particles for use with hard-to-transfect cells

Gene Info

SpeciesGene NameGene IDChromosome LocationIsoform (mRNA) Accession #Protein Accession #OMIM™ Number
HumanCDKN1A10266p21.2NM_000389, NM_001220777, NM_001220778, NM_001291549, NM_078467P38936116899

Is there any possibility to share gRNAs' sequences of p21, claudin-3, claudin-4 knockout plasmids? We plan to perform T7 endonuclease assay. For this, We need to know which exons are targeted by these gRNAs.

Asked by: Ozen
Thank you for your question. We can provide the specific guide RNA (gRNA) sequences for our CRISPR products after you have purchased the products. If you need the targeting exon information prior to purchase, we can provide that information upon request. Please contact our Technical Service Department for support.
Answered by: Technical Support
Date published: 2018-12-03

Can CRISPR knockout plasmids of Santa Cruz be packaged in viruses, or are these plasmids only suitable for transfection?

Asked by: Ozen
Thank you for your question. We do not recommend nor support the use of our CRISPR/Cas9 KO Plasmids for packaging into Lentivirus. We provide them as transfection-ready purified plasmid DNA.
Answered by: Technical Support
Date published: 2018-11-30
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