p21 Waf1/Cip1/CDKN1A Antibody (B-2) is a mouse monoclonal IgG1 κ, cited in 30 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 124-164 at the C-terminus of p21 Waf1/Cip1 of human origin
Anti-p21 Waf1/Cip1/CDKN1A Antibody (B-2) is recommended for detection of p21 Waf1/Cip1 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-p21 Waf1/Cip1/CDKN1A Antibody (B-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of p21 Waf1/Cip1/CDKN1A (B-2): sc-271532.
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p21 Waf1/Cip1/CDKN1A Antibody (B-2). This work is in progress.
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It is now well established that cyclins play a positive role in promoting cell cycle transitions via their ability to associate with and activate their cognate cyclin-dependent kinases (Cdks). Cdk2 associates with cyclins A, D and E, and has been implicated in the control of the G1 to S phase transition in mammals. A novel Cdk-interacting protein, designated p21 Waf1/Cip1, Cip1 or WAF1, has been identified in cyclin A, cyclin D1, cyclin E and Cdk2 immunoprecipitates. p21 Waf1/Cip1 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk 2, cyclin E-Cdk2, cyclin D1-Cdk4 and cyclin D2-Cdk4 complexes. Expression of p21 Waf1/Cip1 is inducible by wildtype, but not mutant, p53. The mouse homolog of p21 Waf1/Cip1 is designated CAP20.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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