P1075A potent KATP (Kir6) channel opener

P1075 (CAS 60559-98-0)

P1075 | CAS 60559-98-0 is rated 5.0 out of 5 by 1.
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Synonym: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine
Application: A potent KATP (Kir6) channel opener
CAS Number: 60559-98-0
Purity: >99%
Molecular Weight: 231.30
Molecular Formula: C12H17N5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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P1075 is a potent KATP (Kir6) channel opener (EC50 for relaxation of aorta = 7.5 nM). P1075 binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).


References

1. Higdon, N.R., et al. 1997. J. Pharmacol. Exp. Ther. 280: 255-260.
2. Gross, I., et al. 1999. Mol. Pharmacol. 56: 1370-1373.
3. Buckner, S.A., et al. 2000 Eur. J. Pharmacol. 400: 287-295.
4. Ashcroft, F.M., and Gribble, F.M., 2000. Trends Pharmacol Sci. 21: 439-445.

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mM), and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
126.16° C (Predicted)
Boiling Point :
347.65° C at 760 mmHg (Predicted)
Density :
1.07 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
Rattus norvegicus: IC50 = 4.4 nM; Mitochondrial complex V; ATP synthase: IC50 = >100 µM (bovine)
Ki Data :
Sulfonylurea receptor 2, Kir6.2: Ki= 27 nM (human)
pK Values :
pKb: 5.12 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
MF0175400
PubChem CID :
43345
MDL Number :
MFCD00914293
Beilstein Registry :
480738
SMILES :
CCC(C)(C)N=C(NC#N)NC1=CN=CC=C1

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Certificate of Analysis

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Rated 5 out of 5 by from Buckner et al Buckner et al. (PubMed ID 10988346) used the KATP channel opener, P1075, to study field- stimulated contractions in pig and human detrusor. -SCBT Publication Review
Date published: 2015-06-29
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