Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Membrane receptor signaling by various ligands, including interferons and growth hormones like EGF, induces activation of Jak kinases, which then leads to tyrosine phosphorylation of the various STAT transcription factors. Activated STAT proteins form dimers, translocate to the nucleus, bind to specific response elements in promoters of target genes, and transcriptionally activate these genes. Stimulation of susceptible cells by interleukin-4 (IL-4) leads to activation of Stat6 through the phosphorylation of tyrosine and serine residues. IL-4 activation of Stat6 also leads to dimerization, which directs Stat6 to the nucleus, and renders it a sequence-specific transcription factor. Stat6 is also tyrosine-phosphorylated in response to IL-15, and is involved in IL-4 activated signaling pathways. The activation of Stat6 by JAK family protein tyrosine kinases is essential for the full response of cells to IL-4.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.