p-MEK-1/2 Antibody (7E10) is a mouse monoclonal IgG1, cited in 30 publications, provided at 50 µg/0.5 ml
raised against phosphopeptide corresponding to amino acid residues surrounding the T-E-Y motif of MEK-1/2 of human origin
recommended for detection of Ser 218 and 222 phosphorylated MEK-1 and Ser 222 and 226 phosphorylated MEK-2 of mouse, rat, human and canine origin by WB and IP
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of p-MEK-1/2 (7E10): sc-81503.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p-MEK-1/2 Antibody (7E10) for WB applications. These reagents are now offered in bundles with p-MEK-1/2 Antibody (7E10) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38β (5,6). MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway (7–9). Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAFor MEKK1) positively regulates the kinase activity..
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.