p-Lck Antibody (pY505.4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
raised against a short amino acid sequence containing phosphorylated Tyr 505 of Lck of human origin
recommended for detection of Tyr 505 phosphorylated Lck of mouse, rat and human origin by WB and IP
m-IgGκ BP-HRP is the preferred secondary detection reagent for p-Lck Antibody (pY505.4) for WB applications. This reagent is now offered in a bundle with p-Lck Antibody (pY505.4) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The Src gene family of membrane-associated protein tyrosine kinases include c-Src, c-Yes, Fyn, Lck, Hck, Lyn, Blk and c-Fgr. The human Lck gene encodes a lymphocyte-specific tyrosine kinase designated pp56 Lck. Rearrangement and overexpression of the Lck gene occurs in select murine lymphomas. Human lymphomas and neuroblastomas frequently exhibit chromosomal abnormalities within a site in the genome that contains the Lck gene. Resting T cells contain high levels of the Lck protein and mRNA, both of which decline upon activation of T cells. Lck expression may contribute to the pathogenesis of some types of neoplastic disease. Csk phosphorylates Lck on Tyr 505. This phosphorylation event supresses Lck catalytic activity under certain conditions. The phosphorylation of Lck at Tyr 394 stimulates Lck activity regardless of Tyr 505 phosphorylation status. In response to T cell antigen receptor binding and subsequent signaling, Lck undergoes phosphorylation on residues that include Tyr 192, Ser 59 and Ser 194.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.