Anti-p-JNK Antibody (14.Thr 183/Tyr 185)recommended for detection of Thr 183 and Tyr 185 phosphorylated JNK1, and correspondingly phosphorylated JNK2 and JNK3 of mouse, rat and human origin by WB, IF and ELISA
p-JNK Antibody (14.Thr 183/Tyr 185) is a mouse monoclonal IgG1 κ, cited in 52 publications, provided at 200 µg/ml
raised against a short amino acid sequence containing phosphorylated Thr 183 and Tyr 185 of JNK of human origin
recommended for detection of Thr 183 and Tyr 185 phosphorylated JNK1, and correspondingly phosphorylated JNK2 and JNK3 of mouse, rat and human origin by WB, IF and ELISA
available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of p-JNK (14.Thr 183/Tyr 185): sc-293136.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p-JNK Antibody (14.Thr 183/Tyr 185) for WB applications. These reagents are now offered in bundles with p-JNK Antibody (14.Thr 183/Tyr 185) (see ordering information below).
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
JNKs (c-Jun N-terminal kinases) belong to a family of MAP kinases that are involved in a variety of cellular processes, including transcriptional regulation and cellular proliferation, differentiation and development. JNK2 (c-Jun N-terminal kinase 2) and JNK3 (c-Jun N-terminal kinase 3) are 424 and 464 amino acid proteins, respectively, that each contain one protein kinase domain and use magnesium as a cofactor to catalyze the phosphorylation of target proteins, thereby playing a role in a variety of events throughout the cell. Both JNK2 and JNK3 exist as multiple alternatively spliced isoforms and are subject to post-translational phosphorylation on Thr 183 and Thr 221, respectively, an event which activates JNK2/JNK3 enzymatic activity. Defects in the gene encoding JNK3 are a cause of epileptic encephalopathy of the Lennox-Gastaut type, a group of epileptic disorders characterized by severe psychomotor delay and seizures.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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