OzagrelA potent and selective thromboxane A2 inhibitor

Ozagrel (CAS 82571-53-7)

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Synonym: Ozagrel, OKY-046
Application: A potent and selective thromboxane A2 inhibitor
CAS Number: 82571-53-7
Purity: 98%
Molecular Weight: 228.2
Molecular Formula: C13H12N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ozagrel, an antithrombic drug, is a potent and selective TXA Synthase (thromboxane A2) inhibitor highly active in human platelets. Found to induce apoptosis in T24 and TCC-SUP bladder cancer cells. Ozagrel improved locomotor activity and coordination in ischemia-reperfusion injured mice models and has potential therapeutic usage for stroke. Reported to inhibit pulmonary thromboxane B2 delivery blocking the increase in systemic vascular resistance. Also shown to inhibit phenolase activities of mushroom tyrosinase.


References

1. Ichikawa, K., et al. 1999. Pharmacology. 59: 257-265. PMID: 10529658
2. Imamura, T., et al. 2003. Arzneimittelforschung. 53: 688-694. PMID: 14650360
3. Westphal, M., et al. 2005. Anesthesiology. 102: 954-961. PMID: 15851882
4. Moussa, O., et al. 2008. Oncogene. 27: 55-62. PMID: 17603559
5. Li, S.B., et al. 2009. Protein J. 28: 182-188. PMID: 19507014

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), DMF (5 mg/ml), 1:1 DMSO:PBS(pH 7.2) (~1 mg/ml), and ethanol (≥1 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
thromboxane A2 synthase: IC50 = 11 nM
pK Values :
pKa: 3.84, pKb: 6.87 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UD3380000
PubChem CID :
5282440
Merck Index :
12: 7115
SMILES :
C1=CC(=CC=C1CN2C=CN=C2)/C=C/C(=O)O

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Certificate of Analysis

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Ozagrel  Product Citations

See how others have used Ozagrel. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 23684750  Abe, Y. et al. 2013. Gastroenterology. 145: 658-67.e11.

PMID: # 18718478  Lee, S. et al. 2008. Microvasc. Res. 76: 217-223.

PMID: # 15000260  Sasaki, K. et al. 2004. J. Med. Invest. 51: 76-83.

PMID: # 10529658  Ichikawa, K. et al. 1999. Pharmacology. 59: 257-265.

PMID: # 7199089  Tanouchi, T. et al. 1981. J. Med. Chem. 24: 1149-1155.

Citations 1 to 5 of 5 total
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