Oxyphenbutazone is a metabolite of Phenylbutazone (sc-204843). Oxyphenbutazone differs from the parent compound by a 4-hydroxyl substitution on one phenyl ring. Oxyphenbutazone is described to produce anti-inflammatory effects and demonstrates inhibition of cytokine production.
1. Matthews, N.S., et al. 2001. Am. J. Vet. Res. 62: 673-675. PMID: 11341383 2. Arifah, A.K. and Lees, P. 2002. J. Vet. Pharmacol. Ther. 25: 299-309. PMID: 12213119 3. Ten Brinke, A., et al. 2005. Eur. Cytokine Netw. 16: 144-151. PMID: 15941686
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Ten Brinke et alTen Brinke et al. (PubMed ID 15941686) found that oxyphenbutazone inhibited in vitro cytokine production by monocytes and lymphocytes peripheral mononuclear cells via Th1 and Th2 lymphokine inactivation. -SCBT Publication Review
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