OxyphenbutazoneA non-steroidal anti-inflammatory agent

Oxyphenbutazone (CAS 129-20-4)

Oxyphenbutazone | CAS 129-20-4 is rated 5.0 out of 5 by 1.
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Synonym: 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
Application: A non-steroidal anti-inflammatory agent
CAS Number: 129-20-4
Molecular Weight: 324.37
Molecular Formula: C19H20N2O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oxyphenbutazone is a metabolite of Phenylbutazone (sc-204843). Oxyphenbutazone differs from the parent compound by a 4-hydroxyl substitution on one phenyl ring. Oxyphenbutazone is described to produce anti-inflammatory effects and demonstrates inhibition of cytokine production.


References

1. Matthews, N.S., et al. 2001. Am. J. Vet. Res. 62: 673-675. PMID: 11341383
2. Arifah, A.K. and Lees, P. 2002. J. Vet. Pharmacol. Ther. 25: 299-309. PMID: 12213119
3. Ten Brinke, A., et al. 2005. Eur. Cytokine Netw. 16: 144-151. PMID: 15941686

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
69-71° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4641
SMILES :
CCCCC1C(=O)N(N(C1=O)C2=CC=C(C=C2)O)C3=CC=CC=C3

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Rated 5 out of 5 by from Ten Brinke et al Ten Brinke et al. (PubMed ID 15941686) found that oxyphenbutazone inhibited in vitro cytokine production by monocytes and lymphocytes peripheral mononuclear cells via Th1 and Th2 lymphokine inactivation. -SCBT Publication Review
Date published: 2015-03-23
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