Oxymetazoline HydrochlorideAn α1-AR and α2-AR adrenergic receptor agonist.

Oxymetazoline Hydrochloride (CAS 2315-02-8)

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Application: An α1-AR and α2-AR adrenergic receptor agonist.
CAS Number: 2315-02-8
Molecular Weight: 296.84
Molecular Formula: C16H24N2O•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oxymetazoline Hydrochloride is a direct sympathomimetic agent. Is a nonselective adrenomimetic of α1A-AR and α2A-AR (α1-AR and α2-AR adrenergic receptor) agonists. Since vascular beds widely express α1 receptors, the action of Oxymetazoline results in vasoconstriction due to its action on endothelial α2 receptors. Oxymetazoline Hydrochloride is an inhibitor of SR-2C and an activator of SR-1A, SR-1B, SR-1D and SR-2C.


References

1. Schoeffter, P., et al. 1991. Eur. J. Pharmacol. 196: 213-216. PMID: 1678720
2. Horie, K., et al. 1995. Br. J. Pharmacol. 116: 1611-1618. PMID: 8564227
3. Widdicombe, J. 1997. Allergy. 52: 7-11. PMID: 9353554
4. Bayorh, M.A., et al. 1997. Clin. Exp. Hypertens. 18: 445-460. PMID: 9140707

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), alcohol (1: 3.6), methanol, DMSO (59 mg/ml), and ethanol (59 mg/ml).
Storage :
Store at room temperature
Melting Point :
300-303° C (dec.)
Boiling Point :
431.9° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
5-HT1b: IC50 = 2 nM (rat); Adrenergic receptor alpha-2: IC50 = 5 nM (rat); SR-1A: EC5050 = 70 nM (human); Short transient receptor potential channel 4: EC5050 = 3.35 µM (mouse); Plasmodium falciparum: IC50 = 10 µM
Ki Data :
SR-1B: Ki= 0.3 nM (human); SR-1D: Ki= 0.4 nM (human); α1A adrenoceptor: Ki= 6 nM; α1B adrenoceptor: Ki= 320 nM; α1C adrenoceptor: Ki= 390 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
66259
Merck Index :
14: 6966
MDL Number :
MFCD00058147
EC Number :
219-015-0
SMILES :
CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C.Cl

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Oxymetazoline Hydrochloride  Product Citations

See how others have used Oxymetazoline Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 14449214  HOTOVY, R. et al. 1961. Arzneimittelforschung. 11: 1016-1022.

Citations 1 to 1 of 1 total
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