Oxymatrine is a compound from Sophora japonica, which has many biologically functions such as the inhibition of IL-6 and IL-1β mRNA expression. Studies indicate that Oxymatrine functions as an inhibitor of hepatitis B virus (HBV) by downregulating the gene coding for heat-stress cognate 70 (Hsc70), which is required for HBV DNA replication. In addition, Oxymatrine inhibits Toll-like receptor 4 (TLR-4)/nuclear factor kappa-B (NF-κB) and reduce apoptosis in neurons. Furthermore, Oxymatrine acts as an inhibitor of β-catenin in MCF-7 breast cancer cells via suppressing its expression.
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