OxymatrineAn inhibitor of IL-6 and IL-1β mRNA expression

Oxymatrine (CAS 16837-52-8)

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Synonym: Matrine N-oxide; Ammothamnine
Application: An inhibitor of IL-6 and IL-1β mRNA expression
CAS Number: 16837-52-8
Purity: ≥98%
Molecular Weight: 264.37
Molecular Formula: C15H24N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).

Oxymatrine is a compound from Sophora japonica, which has many biologically functions such as the inhibition of IL-6 and IL-1β mRNA expression. Studies indicate that Oxymatrine functions as an inhibitor of hepatitis B virus (HBV) by downregulating the gene coding for heat-stress cognate 70 (Hsc70), which is required for HBV DNA replication. In addition, Oxymatrine inhibits Toll-like receptor 4 (TLR-4)/nuclear factor kappa-B (NF-κB) and reduce apoptosis in neurons. Furthermore, Oxymatrine acts as an inhibitor of β-catenin in MCF-7 breast cancer cells via suppressing its expression.


References

1. Wu, Y., et al. 2010. Hua Xi Kou Qiang Yi Xue Za Zhi. 28: 656-659. PMID: 21365847
2. Dong, X.Q., et al. 2010. Inflamm Res. [Epub ahead of print]. PMID: 21190123
3. Zhang, Y., et al. 2010. Med. Oncol. [Epub ahead of print]. PMID: 21069479
4. Shen, X.C., et al. 2011. J Asian Nat Prod Res. 13: 215-224. PMID: 21409682

Physical State :
Solid
Solubility :
Soluble in water (53 mg/ml at 25 °C), ethanol (53 mg/ml at 25 °C), methanol (10 mg/ml), DMSO (53 mg/ml at 25 °C), and DMF (~10 mg/ml).
Storage :
Store at 4° C
Melting Point :
197.6-198° C
Boiling Point :
572.82° C (Predicted)
IC50 :
Hepatitis B virus: EC5050 = 31 µg/ml
pK Values :
pKb: 4.87 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
OQ1770000
PubChem CID :
114850
MDL Number :
MFCD00210339
SMILES :
C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]

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Certificate of Analysis

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Oxymatrine  Product Citations

See how others have used Oxymatrine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25816398  Fei, ZW. et al. 2015. Int J Immunopathol Pharmacol. 28: 201-8.

Citations 1 to 1 of 1 total
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