Oxprenolol hydrochlorideCAS: 6452-73-9
MF: C15H23NO3•HCl
MW: 301.81
A non-selective β-adrenergic antagonist.

Oxprenolol hydrochloride (CAS 6452-73-9)

Oxprenolol hydrochloride | CAS 6452-73-9 is rated 5.0 out of 5 by 1.
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Application: A non-selective β-adrenergic antagonist
CAS Number: 6452-73-9
Purity: >99%
Molecular Weight: 301.81
Molecular Formula: C15H23NO3•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oxprenolol hydrochloride has been reported to be a non-selective β-AR (β-adrenergic receptor) inhibitor that also displays intrinsic sympathomimetic activity. This compound also shows the ability to stabilize cellular membranes and reduce plasma renin activity. Additional data suggests that Oxprenolol hydrochloride demonstrates the ability to counteract the suppressive effects of β-agonist on microglial proliferation.


References

1. Russo, M.E. and Covinsky, J.O. 1983. Pharmacotherapy. 3: 68-81. PMID: 6344036
2. Fujita, H., et al. 1998. Neurosci. Lett. 242: 37-40. PMID: 9509999

Physical State :
Solid
Solubility :
Soluble in water (100 mM), methanol, and ethanol (freely). Insoluble in ether.
Storage :
Store at 4° C
Melting Point :
91-11093° C
Boiling Point :
403.3° C at 760 mmHg
Refractive Index :
n20D ~1.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UA5277000
PubChem CID :
71172
MDL Number :
MFCD00058008
EC Number :
229-260-5
SMILES :
CC(C)NCC(COC1=CC=CC=C1OCC=C)O.Cl

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Certificate of Analysis

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Oxprenolol hydrochloride  Product Citations

See how others have used Oxprenolol hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 22146582  Jeong, I. et al. 2012. Biochem. Pharmacol. 83: 497-505.

PMID: # 29704200  Mol. Neurobiol. 56: 367-377.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Sekut Sekut, L. et al. (PubMed 7882570) evaluated salmeterol as a cytokine inhibitor. They found that it was able to inhibit TNF-alpha secretion by LPS-activated THP-1 cells. This inhibition was effectively reversed by the beta 2-antagonist Oxprenolol, suggesting that inhibition is mediated through the beta 2-adrenergic receptor. -SCBT Publication Review
Date published: 2015-05-19
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