OxaprozinA non-narcotic anti-inflammatory agent shown to inhibit prostaglandin synthesis

Oxaprozin (CAS 21256-18-8)

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Synonym: 4,5-Diphenyl-2-oxazolepropanoic acid
Application: A non-narcotic anti-inflammatory agent shown to inhibit prostaglandin synthesis
CAS Number: 21256-18-8
Molecular Weight: 293.32
Molecular Formula: C18H15NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Anti-inflammatory


References

Todd, P. A., Oxaprozin. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 32, 291, (1986)

Physical State :
Solid
Solubility :
Soluble in water (8.8 mg/L) at 25° C, DMSO, and methanol.
Storage :
Store at -20° C
Melting Point :
161.1-162.8° C
Boiling Point :
467.01° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
ADP-induced human platelet aggregation: IC50 = 100 µM; Alpha-chymotrypsin: IC50 = 200 µM (Bos taurus); Malate Malate dehydrogenase cytoplasmic : IC50 = 175 µM (human); Cyclooxygenase-1: IC50 = 856 nM (human); Beta-lactamase: IC50 = 400 µM
pK Values :
pKa: 4.28 (Predicted), pKb: 0.80 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RP6990000
PubChem CID :
4614
Merck Index :
14: 6924
MDL Number :
MFCD00215977
EC Number :
244-296-1
SMILES :
OC(=O)CCC1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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