Ox40 Antibody (3H1839): sc-71770
- Ox40 Antibody (3H1839) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against OX40 of mouse origin
- recommended for detection of Ox40 cell surface antigen of mouse origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ox40 Antibody (3H1839). This work is in progress.
QUICK LINKS
Ox40 Antibody (3H1839) is a rat monoclonal IgG1 antibody that detects Ox40 in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Ox40, also known as CD134 or Ox40R, plays a crucial role in the immune response by regulating the activation and differentiation of CD4+ T lymphocytes. Anti-Ox40 antibody (3H1839) recognizes a protein primarily located on the surface of activated CD4+ T cells, where Ox40 interacts with its ligand, Ox40L, predominantly expressed on activated B cells. The engagement of Ox40 with Ox40L provides a vital costimulatory signal that enhances T cell activation, promoting effective immune responses. This interaction is particularly important for the generation of robust T helper cell responses, which are essential for orchestrating adaptive immunity and ensuring the body can effectively combat infections and maintain tissue homeostasis. Given its significant role in T cell regulation, Ox40 is also implicated in various immunological conditions, including autoimmune diseases and inflammatory responses, making Ox40 (3H1839) antibody a valuable tool for researchers studying these critical pathways in mouse models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ox40 Antibody (3H1839) References:
- The effect of aging on OX40 agonist-mediated cancer immunotherapy. | Ruby, CE. and Weinberg, AD. 2009. Cancer Immunol Immunother. 58: 1941-7. PMID: 19288101
- The role of OX40-mediated co-stimulation in T-cell activation and survival. | Redmond, WL., et al. 2009. Crit Rev Immunol. 29: 187-201. PMID: 19538134
- The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy. | Moran, AE., et al. 2013. Curr Opin Immunol. 25: 230-7. PMID: 23414607
- OX40 regulates pressure overload-induced cardiac hypertrophy and remodelling via CD4+ T-cells. | Wu, QQ., et al. 2016. Clin Sci (Lond). 130: 2061-2071. PMID: 27580926
- OX40 Regulates Both Innate and Adaptive Immunity and Promotes Nonalcoholic Steatohepatitis. | Sun, G., et al. 2018. Cell Rep. 25: 3786-3799.e4. PMID: 30590049
- IQGAP1 restrains T-cell cosignaling mediated by OX40. | Okuyama, Y., et al. 2020. FASEB J. 34: 540-554. PMID: 31914585
- A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity. | Zhang, H., et al. 2021. Sci Transl Med. 13: PMID: 33504651
- CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer. | Lam, JH., et al. 2021. Cancer Immunol Immunother. 70: 2353-2365. PMID: 33527196
- OX40L/OX40 Signal Promotes IL-9 Production by Mucosal MAIT Cells During Helicobacter pylori Infection. | Ming, S., et al. 2021. Front Immunol. 12: 626017. PMID: 33777009
- OX40 agonist stimulation increases and sustains humoral and cell-mediated responses to SARS-CoV-2 protein and saRNA vaccines. | Duhen, R., et al. 2022. Front Immunol. 13: 896310. PMID: 36238275
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ox40 Antibody (3H1839) | sc-71770 | 200 µg/ml | $322.00 | |||
Ox40 Antibody (3H1839) FITC | sc-71770 FITC | 200 µg/ml | $336.00 | |||
Ox40 Antibody (3H1839) PE | sc-71770 PE | 200 µg/ml | $349.00 |