OSU 03012A PDK1 inhibitor and inducer of caspase and p53-independent apoptosis

OSU 03012 (CAS 742112-33-0)

OSU 03012 | CAS 742112-33-0 is rated 5.0 out of 5 by 1.
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Synonym: AR-12; OSU-03012
Application: A PDK1 inhibitor and inducer of caspase and p53-independent apoptosis
CAS Number: 742112-33-0
Purity: ≥98%
Molecular Weight: 460.45
Molecular Formula: C26H19F3N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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OSU 03012 is a potent inhibitor of PDK1 (IC50 = 5 μM). OSU 03012 causes a dose-dependent induction of cell death regardless of the presence or absence of mutated p53. Studies have shown that upon treatment of cells with OSU 03012 there is an accumulation of reactive oxygen species (ROS) in the cell, which may contribute to cell death through oxidative damage. Exposure to ionizing radiation following treatment with OSU 03012 causes an increase in cell death, which is also caspase-independent.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (11 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 0.5% methylcellulose/0.2% Tween 80 (30 mg/ml at 25 °C).
Storage :
Store at -20° C
Melting Point :
177-180 °C
Boiling Point :
~683.0 °C at 760 mmHg (Predicted)
Density :
~1.36 g/cm3 (Predicted)
Refractive Index :
n20D ~1.65 (Predicted)
IC50 :
Salmonella typhimurium: IC50 = 0.2 µM (Salmonella enterica subsp. enterica serovar Typhimurium); PKB Kinase: IC50 = 5 µM (human); HT-29: IC50 = 7.82 µM (human); RAW264.7: IC50 = 10 µM (mouse)
pK Values :
pKa: 13.29 (Predicted), pKb: 7.47 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10027278
MDL Number :
MFCD12912272
SMILES :
C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. OSU 03012, sc-364560, is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-05-22
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Rated 5 out of 5 by from Mohr et al Mohr et al. (PubMed ID 25986249) found that OSU-03012 inhibited the replication of Lassa, Ebola, Marburg and Nipah viruses via 3-phosphinositide-dependent protein kinase 1 (PDK-1) activation and induction of apoptosis. -SCBT Publication Review
Date published: 2015-06-09
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