Anti-OSBP2 Antibody (A-3) is a mouse monoclonal IgG1 κ OSBP2 antibody, cited in 1 publications, provided at 200 µg/ml
raised against amino acids 1-190 mapping at the N-terminus of OSBP2 of mouse origin
Anti-OSBP2 Antibody (A-3) is recommended for detection of OSBP2 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-OSBP2 Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of OSBP2 (A-3): sc-376601.
m-IgG Fc BP-HRP is the preferred secondary detection reagent for OSBP2 Antibody (A-3) for WB applications. This reagent is now offered in a bundle with OSBP2 Antibody (A-3) (see ordering information below).
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
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Labware ships FedEx Ground free of charge to the contiguous US
OSBP2 Antibody (A-3) is a high quality monoclonal OSBP2 antibody (also designated OSBP2 antibody) suitable for the detection of the OSBP2 protein of mouse, rat and human origin. OSBP2 Antibody (A-3) is available as both the non-conjugated anti-OSBP2 antibody form, as well as multiple conjugated forms of anti-OSBP2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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