Ophiobolin C is a phytotoxic metabolite from the Ophiobolin class produced by many species of the genus Bipolaris. Studies suggest that Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells. In addition, the culture medium is a key component for the production of a specific Ophiobolin from the same organism. It has been reported that B. maydis will produce Ophiobolin A (sc-202266), B (sc-202267), and L if cultured in liquid medium, while in contrast produce Ophiobolin C and K in solid substratum medium. The structure of Ophiobolin C is comprised of five isoprene units linked together to form the backbone of the molecule.
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