CysLT1 antagonist. Downplays contraction of smooth airway muscle, microvascular leakage into airways and eosinophil infiltration. Potential to decrease symptoms of bronchial asthma.
Lynch et al (1999) Characterization of the human leukotriene CysLT1 receptor. Nature 399 789. Heise et al (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J.Biol.Chem. 275 30531. Suzuki et al (2003) Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078). J.Asthma 40 395.
Soluble in DMSO (50 mM), methanol, DMF (~20 mg/ml), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Store at 4° C
741.25° C (Predicted)
~1.4 g/cm3 (Predicted)
n20D 1.68 (Predicted)
CysLT1 Receptor: IC50 = 0.8 nM (human); U-937: IC50 = 1 nM; Binds to the human CysLT1: IC50 = 4-7 nM; Binds to the human CysLT2: IC50 = 3.6 µM; Cruzipain: IC50 = 7 µM (Trypanosoma cruzi)
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.