OndansetronA serotonin 5-HT3 receptor antagonist

Ondansetron (CAS 99614-02-5)

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Application: A serotonin 5-HT3 receptor antagonist
CAS Number: 99614-02-5
Purity: ≥99%
Molecular Weight: 293.4
Molecular Formula: C18H19N3O
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Ondansetron is an antagonist of the SR (serotonin 5-HT3 receptor). Agonism of the SR (5-HT3 receptor) by Ondansetron has been correlated to anti-emetic effects.


References

1. Seynaeve, C., et al. 1991. Anticancer Drugs. 2: 343-355. PMID: 1665723
2. Cubeddu, L.X., et al. 1994. Am. J. Clin. Oncol. 17: 137-146. PMID: 8141105
3. Ito, H., et al. 1995. Neuropharmacology. 34: 631-637. PMID: 7566499

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/mL, warm), water (partly miscible), and DMF.
Storage :
Desiccate at -20° C
Melting Point :
235-237° C (Predicted)
Boiling Point :
545.98° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Serotonin 3a (5-HT3a) receptor: IC50 = 1.4 nM (rat); Serotonin 3b (5-HT3b) receptor: IC50 = 6.8 nM (rat); Neuronal acetylcholine receptor; alpha3/beta4: IC50 = 27000 nM (human); Neuronal acetylcholine receptor; alpha4/beta2: IC50 = 66000 nM (human); Cytochrome P450 3A4: IC50 = 11000 nM (human)
Ki Data :
Serotonin 3b (5-HT3b) receptor: Ki= 7.6 nM (rat); Serotonin 3a (5-HT3a) receptor: Ki= 12 nM (human); Voltage-gated L-type calcium channel alpha-1D subunit: Ki= 5400 nM (rat); Mu opioid receptor: Ki= 2900 nM (rat); Dopamine D1 receptor: Ki= >10000 nM (rat)
pK Values :
pKa: 7.50
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4595
Merck Index :
14: 6848
MDL Number :
MFCD00764297
SMILES :
CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C

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Ondansetron  Product Citations

See how others have used Ondansetron. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28675564  Donnelly, WT. et al. 2017. Exp. Physiol. 102: 1007-1018.

Citations 1 to 1 of 1 total
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