OndansetronA serotonin 5-HT3 receptor antagonist

Ondansetron (CAS 99614-02-5)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 51ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: A serotonin 5-HT3 receptor antagonist
CAS Number: 99614-02-5
Purity: ≥99%
Molecular Weight: 293.4
Molecular Formula: C18H19N3O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ondansetron is an antagonist of the SR (serotonin 5-HT3 receptor). Agonism of the SR (5-HT3 receptor) by Ondansetron has been correlated to anti-emetic effects.


1. Seynaeve, C., et al. 1991. Anticancer Drugs. 2: 343-355. PMID: 1665723
2. Cubeddu, L.X., et al. 1994. Am. J. Clin. Oncol. 17: 137-146. PMID: 8141105
3. Ito, H., et al. 1995. Neuropharmacology. 34: 631-637. PMID: 7566499

Physical State :
Solubility :
Soluble in DMSO (10 mg/mL, warm), water (partly miscible), and DMF.
Storage :
Desiccate at -20° C
Melting Point :
235-237° C (Predicted)
Boiling Point :
545.98° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Serotonin 3a (5-HT3a) receptor: IC50 = 1.4 nM (rat); Serotonin 3b (5-HT3b) receptor: IC50 = 6.8 nM (rat); Neuronal acetylcholine receptor; alpha3/beta4: IC50 = 27000 nM (human); Neuronal acetylcholine receptor; alpha4/beta2: IC50 = 66000 nM (human); Cytochrome P450 3A4: IC50 = 11000 nM (human)
Ki Data :
Serotonin 3b (5-HT3b) receptor: Ki= 7.6 nM (rat); Serotonin 3a (5-HT3a) receptor: Ki= 12 nM (human); Voltage-gated L-type calcium channel alpha-1D subunit: Ki= 5400 nM (rat); Mu opioid receptor: Ki= 2900 nM (rat); Dopamine D1 receptor: Ki= >10000 nM (rat)
pK Values :
pKa: 7.50
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
Merck Index :
14: 6848
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Ondansetron  Product Citations

See how others have used Ondansetron. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28675564  Donnelly, WT. et al. 2017. Exp. Physiol. 102: 1007-1018.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 217ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 193ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.