Oncrasin 1A proapoptotic compound

Oncrasin 1 (CAS 75629-57-1)

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Synonym: 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
Application: A proapoptotic compound
CAS Number: 75629-57-1
Purity: >99%
Molecular Weight: 269.73
Molecular Formula: C16H12CINO
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oncrasin 1 is a proapoptotic substance. Induces abnormal nuclear aggregation of PKCι and suppressing RNA transcription. Displays antiproliferative effects against various human tumor cell lines. Shown to inhibit human xenograft growth by 75% in vivo.


References

Guo et al (2007) Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. Cancer Res. 68 7403. Guo et al (2009) Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol.Cancer Ther. 8 441.

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mM), and DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
150.92° C (Predicted)
Boiling Point :
~465.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Induces apoptosis in cells harboring mutant K-Ras: IC50 = 0.11 µM (H2887); Induces apoptosis in cells harboring mutant K-Ras: IC50 = 0.25 µM (H460); Induces apoptosis in cells harboring mutant K-Ras: IC50 = 1.0 µM (H2122); Induces apoptosis in cells harboring mutant K-Ras: IC50 = 1.58 µM (A549); Induces apoptosis in cells harboring mutant K-Ras: IC50 = 4.81 µM (T29Kt1)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
872445
MDL Number :
MFCD01051808
SMILES :
C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)C=O

Download SDS (MSDS)

Certificate of Analysis

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