OmeprazoleA selective proton pump and CYP inhibitor

Omeprazole (CAS 73590-58-6)

Omeprazole | CAS 73590-58-6 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_21, h_24
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202265, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 52ms
  • REVIEWS, PRODUCT
Synonym: Losec; Omesec; Prilosec
Application: A selective proton pump and CYP inhibitor
CAS Number: 73590-58-6
Purity: ≥99%
Molecular Weight: 345.42
Molecular Formula: C17H19N3O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Omeprazole is a cell-permeable, selective proton pump inhibitor. Omeprazole undergoes an acid-catalyzed rearrangement to a thiol-reactive cationic sulfenamide that inhibits (H+-K+)-ATPase in the gastric milieu. Omeprazole also acts as an aryl hydrocarbon-like inducer of cytochrome P450 secretion in human liver. This compound is an inhibitor a variety of CYP isoenzymes, including CYP2C19, CYP2C9 and CYP3A.


References

Lambrecht, N., et al. 2000. J. Biol. Chem. 275, 4041. Besancon, M., et al. 1997. J. Biol. Chem. 272, 22438. Sachs, G., et al. 1995. Ann. Rev. Pharmacol. Toxicol. 35, 277. Diaz, D., et al. 1990. Gastroenterology 99, 737. Fellenius, E., et al. 1981. Nature 290, 159.

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml).
Storage :
Store at 4° C
Melting Point :
156.2-157.2° C
Boiling Point :
599.99° C at 760 mmHg (Predicted)
Density :
1.37 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
Giardia intestinalis: IC50 = 95.5 nM; Trichomonas vaginalis: IC50 = 121.6 nM; Potassium-transporting ATPase: IC50 = 250 nM (hamster); Plasmodium berghei: IC50 = 291 nM; Entamoeba histolytica: IC50 = 492.2 nM
Ki Data :
CYP2C19: Ki= 3.1 µM; CYP2C9: Ki= 40.1 µM; CYP3A: Ki= 84.4 µM
pK Values :
pKa: 6.86 (Predicted), pKb: 3.08 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
DD9087000
PubChem CID :
4594
Merck Index :
14: 6845
MDL Number :
MFCD00083192
Beilstein Registry :
3628192
SMILES :
CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Omeprazole  Product Citations

See how others have used Omeprazole. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28949811  Quinney, SK. et al. 2017. Fetal Pediatr Pathol. 36: 400-411.

PMID: # 25141173  Novotna, A. et al. 2014. PLoS ONE. 9: e105580.

PMID: # 24887303  Novotna, A. et al. 2014. PLoS ONE. 9: e98711.

Citations 1 to 3 of 3 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 88ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Lee Lee, YY. et al. (PubMed 26418900) reported that proton pump inhibitors, such as Omeprazole, enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma. -SCBT Publication Review
Date published: 2015-06-28
  • y_2019, m_9, d_21, h_24
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202265, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 130ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.