OligomycinA specific inhibitor of the mitochondrial ATP-synthase

Oligomycin (CAS 1404-19-9)

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Synonym: Oligomycin a, b, c mixture
Application: A specific inhibitor of the mitochondrial ATP-synthase
CAS Number: 1404-19-9
Molecular Weight: 791.06
Molecular Formula: C45H74O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. The compound is a mixture of isomers A (sc-201551), B (sc-202262), and C (sc-202263). Cancer cell studies show that Oligomycin does not activate the hypoxia-induced factor, however, it enhances the bioenergetic adaptation of heterogeneous bioenergetically organized cells. Oligomycin has been shown to decreased the cyclin D1 protein expression levels.


References

1. Wolvetang, E.J., et al. 1994. FEBS Lett. 339: 40-44. PMID: 8313978
2. Salomon, A.R., et al. 2001. Org. Lett. 3: 57-59. PMID: 11429871
3. Kanai, M., et al. 2009. J. Antibiot. 62: 425-429. PMID: 19575044
4. Hao, W., et al. 2010. J. Biol. Chem. 285: 12647-12654. PMID: 20110356

Physical State :
Solid
Solubility :
Soluble in EtOH, acetone (50 mg/ml), DMSO (300 mg/ml), ethanol, and methanol. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
150° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RK3325000
PubChem CID :
6450197
Merck Index :
14: 6833
MDL Number :
MFCD01779388
EC Number :
215-767-9
SMILES :
CCC/1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)/C=C/C(C(C(C(=O)C(C(C(C(=O)C(C(C(C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C

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Certificate of Analysis

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Oligomycin  Product Citations

See how others have used Oligomycin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27083147  Eakins, J. et al. 2016. Toxicol In Vitro. 34: 161-170.

PMID: # 26604148  Casadei, N. et al. 2016. Hum. Mol. Genet. 25: 459-71.

Citations 1 to 2 of 2 total

What is the %Oligomycin A of the product?

Asked by: JH 00
Thank you for your question. Oligomycin (CAS 1404-19-9) sc-203342 is a mixture of Oligomycin a, b, and c. The percentages of Oligomycin vary from lot to lot. To find out the composition of your lot or the lot that is currently available please contact our technical service directly.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06

Is this product a mixture of isomers?

Asked by: hawkeye11
This chemical, Oligomycin (CAS 1404-19-9), contains a mixture of Oligomycin A, Oligomycin B and Oligomycin C.
Answered by: Chemical Support 1
Date published: 2017-03-16

What's the grade or purity for this?

Asked by: smqbest
Thank you for your question. This information can vary for each lot. The current lot we have in-stock has a >99% purity. Here is a link to the most current CoA: https://datasheets.scbt.com/coa/coa.php?sc=sc-203342&lot=E1216 Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Tech Service
Date published: 2016-10-26

what is the grade (for example > 98%) of this oligomycin?

Asked by: laboratory
Thank you for your question. This information can vary for each lot. The current lot we have in-stock has a >99% purity. Here is a link to the most current CoA: https://datasheets.scbt.com/coa/coa.php?sc=sc-203342&lot=E1216 Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Tech Service
Date published: 2016-10-26
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