OLIG2 Antibody (1G11): sc-293163

OLIG2 Antibody (1G11) is a mouse monoclonal IgG1 kappa light chain antibody that detects OLIG2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). OLIG2 (1G11) antibody is available as the non-conjugated form. OLIG2, a member of the basic helix-loop-helix (bHLH) transcription factor family, plays a crucial role in the development of oligodendrocytes, which are essential for the formation of myelin sheaths that insulate nerve fibers in the central nervous system. This myelination is vital for proper neuronal function and signal transmission, and disruptions in OLIG2 expression can lead to various neurological disorders. OLIG2 is predominantly expressed in the embryonic brain and is involved in regulating oligodendrogenesis, making OLIG2 a key player in the development of the nervous system. Additionally, OLIG2 interacts with the Nkx-2.2 homeodomain protein, which is critical for ventral neuronal patterning during embryonic development. OLIG2 expression is significantly elevated in oligodendrogliomas, a type of brain tumor, while remaining nearly absent in astrocytomas, highlighting OLIG2′s potential as a molecular marker for glial brain tumors. Given OLIG2′s importance in both normal development and disease, anti-OLIG2 antibody (1G11) serves as a valuable tool for researchers studying oligodendrocyte biology and related pathologies.

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OLIG2 Antibody (1G11) References:

1. Olig2 transcription factor in the developing and injured forebrain; cell lineage and glial development.  |  Ono, K., et al. 2009. Mol Cells. 27: 397-401. PMID: 19390819
2. OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes.  |  Liao, Y., et al. 2021. Neuro Oncol. 23: 1183-1196. PMID: 33539525
3. Olig2 regulates p53-mediated apoptosis, migration and invasion of melanoma cells.  |  Lee, JE., et al. 2021. Sci Rep. 11: 7778. PMID: 33833342
4. Shh and Olig2 sequentially regulate oligodendrocyte differentiation from hiPSCs for the treatment of ischemic stroke.  |  Xu, J., et al. 2022. Theranostics. 12: 3131-3149. PMID: 35547747
5. OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.  |  Xu, Z., et al. 2022. Clin Cancer Res. 28: 4278-4291. PMID: 35736214
6. Identifying an oligodendrocyte enhancer that regulates Olig2 expression.  |  Fan, C., et al. 2023. Hum Mol Genet. 32: 835-846. PMID: 36193754
7. Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination.  |  Wang, J., et al. 2022. J Neurosci. 42: 8542-8555. PMID: 36198499
8. Oligodendrocyte progenitor cell-specific delivery of lipid nanoparticles loaded with Olig2 synthetically modified messenger RNA for ischemic stroke therapy.  |  Xu, J., et al. 2024. Acta Biomater. 174: 297-313. PMID: 38096960
9. Utility of combining OLIG2 and SOX10 IHC expression in CNS tumours: promising biomarkers for subtyping paediatric- and adult-type gliomas.  |  Aboubakr, O., et al. 2024. Histopathology. 84: 893-899. PMID: 38253970
10. Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration.  |  Myers, BL., et al. 2024. Nat Commun. 15: 10363. PMID: 39609428

The preferred OLIG2 antibody is OLIG2 Antibody (H-10): sc-515947.