Oleylethanolamide is a naturally occurring lipid analogue of the endogenous cannabinoid anandamide (sc-200790). This compound has been noted to be produced in cells and is quickly eliminated by enzymatic hydrolysis. Experiments suggest that Oleylethanolamide causes activation of Neu/ErbB2 receptors and is a selective agonist of GPR55. It is also an endogenous agonist at the GPR119 receptor. Additional studies suggest that this agent can cause Sr/Thr phosphorylation of Glut4 via partial mediation of p38 and JNK kinases. Oleylethanolime has been noted to also regulate the expression of various PPAR-α target genes. Oleylethanolamide is an inhibitor of Acid Ceramidase and an activator of PPARα and VR1.
1. Rodríguez de Fonseca, F., et al. 2001. Nature. 414: 209-212. PMID: 11700558 2. Fu, J., et al. 2003. Nature. 425: 90-93. PMID: 12955147 3. González-Yanes, C., et al. 2005. Am. J. Physiol. Endocrinol. Metab. 289: E923-E929. PMID: 15886223 4. Su, H.F., et al. 2006. Endocrinology. 147: 827-834. PMID: 16269455
Soluble in chloroform, DMSO (>25 mg/ml), ethanol (>25 mg/ml), methanol, and DMF (~100 mg/ml).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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What is the appearance of the compound?
Asked by: two2igm05
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Su et alSu et al. (PubMed ID 16269455) found that oleylethanolamide reduced the progression of systolic/diastolic dysfunction and ventricular remodeling by preventing doxorubicin-induced apoptosis via Ras-Raf-1-Mek-Erk signaling activation. -SCBT Publication Review
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