Oleyl Anilide (OA), a weak inhibitor of ACAT (IC50 = 26 µM), can be found in denatured anilide cooking oil. Oleyl anilide and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to toxic oil syndrome (TOS), resulting in eosinophilia, excessive T-cell activation, and elevated interleukin-4 (IL-4), soluble IL-2R, and IL-5, as well as acute pulmonary inflammatory reaction followed by chronic neuropathy, myalgia, and autoimmune connective tissue disease.
1. Roth, B D., et al., 1992. Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. Journal of medicinal chemistry. 35(9): 1609-17. PMID: 1578488
2. Suckling, K E., et al., 1985. Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism. Journal of lipid research. 26(6): 647-71. PMID: 3897424
3. Gelpí, Emilio., et al., 2002. The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge. Environmental health perspectives. 110(5): 457-64. PMID: 12003748
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