Oleoyl Ethanolamide-d4

Oleoyl Ethanolamide-d4 (CAS 946524-36-3)

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Synonym: OEA-d4; Oleic Acid Ethanolamide-d4
Application: An internal standard for the quantification of oleoyl ethanolamide
CAS Number: 946524-36-3
Molecular Weight: 329.55
Molecular Formula: C20H35D4NO2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate. It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue but its biosynthesis is reduced in the intestine of rats following food deprivation. OEA is an endogenous, potent agonist for PPARα, exhibiting an EC50 value of 120 nM in a transactivation assay. Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice. These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.


1 di Tomaso, E., Beltramo, M., Piomelli, D. Brain cannabinoids in chocolate. Nature 382 677-678 (1996). 2 Epps, D.E., Palmer, J.W., Schmid, H.H.O., et al. Inhibition of permeability-dependent Ca2+ release from mitochondria by N-acelethanolamines, a class of lipids synthesized in ischemic heart tissue. J Biol Chem 257 1383-1392 (1982). 3 de Fonseca, F.R., Navarro, M., Gómez, R., et al. An anorexic lipid mediator regulated by feeding. Nature 414 209-212 (2001). 4 Fu, J., Gaetani, S., Oveisi, F., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α Nature 425, 90-93 (2003).

Formulation :
A solution in ethanol
Appearance :
Physical State :
Solubility :
Soluble in DMSO (~100 mg/ml), DMF (~100 mg/ml), and ethanol.
Storage :
Desiccate at -20° C
Boiling Point :
78.0-80.0° C
Refractive Index :
n20D ~1.47 (Predicted)
IC50 :
PPARα: EC5050 = 120 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1170, Class 3, Packing group II
PubChem CID :
MDL Number :

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Certificate of Analysis

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