Oleic Acid, a monounsaturated fatty acid originally derived from Olea europaea, has been shown to be an anti-proliferative agent. This compound has also been reported to promote neuronal differentiation in murine cell cultures. Mechanistic studies suggest that these Oleic Acid effects are mediated by PPARβ. Furthermore, Oleic Acid has demonstrated the ability to stimulate an increase in secretion of collagen I, TGF-β secretion, and extracellular signal-regulated kinase1/2. Oleic Acid is an activator of PKC and CaMKII.
1. Díaz-Guerra, M.J., et al. 1991. J. Biol. Chem. 266: 23568-23576. PMID: 1748635 2. Waterman, E., et al. 2007. Altern Med Rev. 12: 331-342. PMID: 18069902 3. Di Loreto, S., et al. 2007. J. Cell. Physiol. 211: 837-847. PMID: 17390299 4. Mishra, R., et al. 2008. Arterioscler. Thromb. Vasc. Biol. 28: 541-547. PMID: 18096831
Soluble in ethanol (>25 mg/ml), ether, acetone, chloroform, DMF (100 mg/ml), DMSO (100 mg/ml), and PBS (pH 7.2) (<100 µg/ml).
Store at -20° C
13-14° C (lit.)
194-195° C (lit.) at 1.2 mmHg
0.89 g/mL at 25° C
DNA topoisomerase I: IC50 = 31000 nm (human); Fatty acid binding protein adipocyte: IC50 = 26100 nm (human)
Rated 5 out of
KansanenKansanen, E. et al. (PubMed 19808663) used Oleic Acid, a monounsaturated fatty acid and antiproliferating agent, on control and Nrf2-small interfering RNA-transfected human endothelial cells, to study Nrf2-dependent/independent effects of OA-NO2 on gene expression. They found that the majority of OA-NO2-regulated genes were regulated by Nrf2-independent pathways. -SCBT Publication Review
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