Oleic AcidAn anti-proliferative agent and activator of PKC and CaMKII

Oleic Acid (CAS 112-80-1)

Oleic Acid | CAS 112-80-1 is rated 5.0 out of 5 by 1.
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Synonym: cis-9-Octadecenoic acid;Elainic acid
Application: An anti-proliferative agent and activator of PKC and CaMKII
CAS Number: 112-80-1
Purity: ≥99%
Molecular Weight: 282.46
Molecular Formula: C18H34O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oleic Acid, a monounsaturated fatty acid originally derived from Olea europaea, has been shown to be an anti-proliferative agent. This compound has also been reported to promote neuronal differentiation in murine cell cultures. Mechanistic studies suggest that these Oleic Acid effects are mediated by PPARβ. Furthermore, Oleic Acid has demonstrated the ability to stimulate an increase in secretion of collagen I, TGF-β secretion, and extracellular signal-regulated kinase1/2. Oleic Acid is an activator of PKC and CaMKII.


References

1. Díaz-Guerra, M.J., et al. 1991. J. Biol. Chem. 266: 23568-23576. PMID: 1748635
2. Waterman, E., et al. 2007. Altern Med Rev. 12: 331-342. PMID: 18069902
3. Di Loreto, S., et al. 2007. J. Cell. Physiol. 211: 837-847. PMID: 17390299
4. Mishra, R., et al. 2008. Arterioscler. Thromb. Vasc. Biol. 28: 541-547. PMID: 18096831

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol (>25 mg/ml), ether, acetone, chloroform, DMF (100 mg/ml), DMSO (100 mg/ml), and PBS (pH 7.2) (<100 µg/ml).
Storage :
Store at -20° C
Melting Point :
13-14° C (lit.)
Boiling Point :
194-195° C (lit.) at 1.2 mmHg
Density :
0.89 g/mL at 25° C
Refractive Index :
n20D 1.46
IC50 :
DNA topoisomerase I: IC50 = 31000 nm (human); Fatty acid binding protein adipocyte: IC50 = 26100 nm (human)
Ki Data :
Fatty acid-binding protein, liver: Ki= 180 nm (Rattus norvegicus); Fatty acid binding protein adipocyte: Ki= 185 nm (human); Fatty acid binding protein epidermal: Ki= 248 nm (human)
pK Values :
pKa: 4.78
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
RG2275000
PubChem CID :
445639
Merck Index :
14: 6828
MDL Number :
MFCD00064242
EC Number :
204-007-1
Beilstein Registry :
1726542
SMILES :
CCCCCCCC/C=C\\CCCCCCCC(=O)O

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Certificate of Analysis

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Oleic Acid  Product Citations

See how others have used Oleic Acid. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28819452  Chen, L. et al. 2017. Theranostics. 7: 2634-2648.

PMID: # 19808663  Kansanen, E. et al. 2009. J. Biol. Chem. 284: 33233-33241.

Citations 1 to 2 of 2 total

for oral feeding of oleic acid ,which solvent can be used to dissolve solid oleic acid , and how much oleic acid can be dissolved per ml of solvent

Asked by: aksindia
Thank you for your question. This chemical is for in vitro research use only.
Answered by: Technical Support
Date published: 2019-06-16

What is the anti solvent of Oleic acid

Asked by: Moran
Thank you for your question. Oleic Acid is soluble in ethanol (&gt;25 mg/ml), ether, acetone, chloroform, DMF (100 mg/ml), DMSO (100 mg/ml), and PBS (pH 7.2) (&lt;100 &micro;g/ml).
Answered by: Technical Support
Date published: 2019-03-22
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Rated 5 out of 5 by from Kansanen Kansanen, E. et al. (PubMed 19808663) used Oleic Acid, a monounsaturated fatty acid and antiproliferating agent, on control and Nrf2-small interfering RNA-transfected human endothelial cells, to study Nrf2-dependent/independent effects of OA-NO2 on gene expression. They found that the majority of OA-NO2-regulated genes were regulated by Nrf2-independent pathways. -SCBT Publication Review
Date published: 2015-02-20
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