OleamideA CB1, 5-HT2A and 2C receptor agonist

Oleamide (CAS 301-02-0)

Oleamide | CAS 301-02-0 is rated 5.0 out of 5 by 1.
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Synonym: 9,10-Octadecenoamide
Application: A CB1, 5-HT2A and 2C receptor agonist
CAS Number: 301-02-0
Molecular Weight: 281.48
Molecular Formula: C18H35NO
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oleamide is an endogenous lipid. Oleamide acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Oleamide also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.


References

1. Cravatt, B.F., et al 1995. Science. 268: 1506-1509. PMID: 7770779
2. Huidobro-Toro, J.P., et al. 1996. Proc. Natl .Acad. Sci. USA. 93: 8078-8082. PMID: 8755606
3. Hedlund, P.B., et al. 1999. Biochem. Pharmacol. 58: 1807-1813. PMID: 10571256
4. Leggett, J.D., et al. 2004. Br. J. Pharmacol. 141: 253-262. PMID: 14707029

Physical State :
Solid
Solubility :
Soluble in chloroform (50 mg/ml), ethanol (100 mM), DMSO (~14 mg/ml), and DMF (~14 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
66-72 °C
Boiling Point :
>260 °C
Density :
0.88 g/cm3 (Predicted)
Refractive Index :
n20D 1.47 (Predicted)
IC50 :
CB1 cannabinoid receptor: EC5050 = 1.64 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
RG2230000
PubChem CID :
5283387
MDL Number :
MFCD00053638
EC Number :
206-103-9
Beilstein Registry :
1726539
SMILES :
CCCCCCCC/C=CCCCCCCCC(=O)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Leggett et al Leggett et al. (PubMed ID 14707029) found that oleamid is a full cannabinoid CB(1) receptor agonist. -SCBT Publication Review
Date published: 2015-03-02
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