Oleamide is an endogenous lipid. Oleamide acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Oleamide also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.
1. Cravatt, B.F., et al 1995. Science. 268: 1506-1509. PMID: 7770779 2. Huidobro-Toro, J.P., et al. 1996. Proc. Natl .Acad. Sci. USA. 93: 8078-8082. PMID: 8755606 3. Hedlund, P.B., et al. 1999. Biochem. Pharmacol. 58: 1807-1813. PMID: 10571256 4. Leggett, J.D., et al. 2004. Br. J. Pharmacol. 141: 253-262. PMID: 14707029
Soluble in chloroform (50 mg/ml), ethanol (100 mM), DMSO (~14 mg/ml), and DMF (~14 mg/ml). Insoluble in water.
Store at -20° C
0.88 g/cm3 (Predicted)
n20D 1.47 (Predicted)
CB1 cannabinoid receptor: EC5050 = 1.64 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Leggett et alLeggett et al. (PubMed ID 14707029) found that oleamid is a full cannabinoid CB(1) receptor agonist. -SCBT Publication Review
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