OlaparibA potent inhibitor of PARP

Olaparib (CAS 763113-22-0)

Olaparib | CAS 763113-22-0 is rated 5.0 out of 5 by 1.
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Synonym: 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine
Application: A potent inhibitor of PARP
CAS Number: 763113-22-0
Purity: >99%
Molecular Weight: 434.47
Molecular Formula: C24H23FN4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Olaparib is a potent inhibitor of both PARP-1 and PARP-2, with IC50 = 5 nM and 1 nM, respectively. Olaparib is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus activating BRCA2-dependent recombination pathways.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (33 mg/mL), ethanol (1.7 mg/mL), and water (<1 mg/mL) at 25 °C.
Storage :
Store at -20° C
Melting Point :
198-209° C
Density :
1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
PARP-1: IC50 = 5 nM; PARP-2: IC50 = 1 nM; PF50: IC50 = 25.8 µM; Tankyrase-1: IC50 = 1500 nM (human)
pK Values :
pKa: 12.07 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23725625
Merck Index :
14: 10415
MDL Number :
MFCD13185161
SMILES :
C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

Download SDS (MSDS)

Certificate of Analysis

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Olaparib  Product Citations

See how others have used Olaparib. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30784586  Munnur, D.|Somers, J.|Skalka, G.|Weston, R.|Jukes-Jones, R.|Bhogadia, M.|Dominguez, C.|Cain, K.|Ahel, I.|Malewicz, M.| et al. 2019. Cell Rep. 26: 2028-2036.e6.

PMID: # 28069876  Li, J. et al. 2017. Mol. Cancer Ther.

Citations 1 to 2 of 2 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Olaparib, sc-302017, is a white or off-white solid.
Answered by: TechService7
Date published: 2017-02-15
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Rated 5 out of 5 by from Works well for cell culture and animal studies Works well for cell culture and animal studies.
Date published: 2015-06-08
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