Okadaic Acid, Potassium SaltCAS: 155751-72-7
MF: C44H67O13•K
MW: 843.1
A PP1/PP2A/PP2B/PP2C inhibitor, used to study tumor promotion/NO metabolism/apoptosis.

Okadaic Acid, Potassium Salt (CAS 155751-72-7)

Okadaic Acid, Potassium Salt | CAS 155751-72-7 is rated 5.0 out of 5 by 1.
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Synonym: Halochondrine A, Potassium Salt
Application: A PP1/PP2A/PP2B/PP2C inhibitor, used to study tumor promotion/NO metabolism/apoptosis
CAS Number: 155751-72-7
Purity: >98%
Molecular Weight: 843.1
Molecular Formula: C44H67O13•K
* Refer to Certificate of Analysis for lot specific data (including water content).
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Okadaic Acid, Potassium Salt is a water-soluble analog of Okadaic Acid, isolated from cultured Prorocentrum concavum. The salt form is generated in aqueous potassium hydroxide methanol solution. The compound is a potent inhibitor of serine/threonine-specific protein phosphatases PP1, PP2A, 5534, PP2C and endogenous phosphatase smooth muscle myosin at IC50 of 10-15 nM, 0.1 nM, 5 μM, >10 μM and 15-70 nM respectively. This inhibition action has been used to stimulate the activity of glucose transport and has been observed to block insulin's stimulation of glucose transport by inhibiting IRS-1 phosphorylation. Okadaic Acid, Potassium Salt has been used as a response modifier in the study of large granular lymphocyte and T-cell biochemistry. In addition to inhibitive activities it is a tumor promoter and has been used to study nitric oxide metabolism, apoptosis, cell cycle and calcium signaling.


References

1. Karaki, H., et al. 1989. Br. J. Pharmacol. 98: 590-596. PMID: 2555015
2. Lawrence, J.C., et al. 1990. J. Biol. Chem. 265: 19768-19776. PMID: 2174052
3. Cohen, P., et al. 1990. Trends Biochem. Sci. 15: 98-102. PMID: 2158158
4. Jullien, D., et al. 1993. J. Biol. Chem. 268: 15246-15251. PMID: 8392070
5. Wright, S.C., et al. 1993. J. Cell. Biochem. 53: 222-233. PMID: 8263039
6. McVicar, D.W., et al. 1994. Eur. J. Immunol. 24: 165-170. PMID: 8020552

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water, ethanol, methanol, acetone, ethyl acetate, chloroform
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44134868
SMILES :
CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)[O-])O)O)C)O)O.[K+]

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Okadaic Acid, Potassium Salt  Product Citations

See how others have used Okadaic Acid, Potassium Salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

Marquette, C. A. et al. 1999. Analytica Chimica Acta. 398: 173-182.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Gong Gong, FR. et al. (PubMed 26053095) found that Okadaic Acid (Halochondrine A), an inhibitor of PP1, PP2A, PP2B, PP2C, arrested the cell cycle at the G2 phase through a a mechanism that was dependent on the JNK pathway. -SCBT Publication Review
Date published: 2015-03-24
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