OdanacatibA cathepsin K inhibitor

Odanacatib (CAS 603139-19-1)

Odanacatib | CAS 603139-19-1 is rated 5.0 out of 5 by 1.
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Synonym: N-(1-cyanocyclopropyl)-4-fluoro-N2-{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)biphenyl-4-yl]ethyl}-L-leucinamide
Application: A cathepsin K inhibitor
CAS Number: 603139-19-1
Purity: ≥98%
Molecular Weight: 525.59
Molecular Formula: C25H27F4N3O3S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Odanacatib is an inhibitor of cathepsin K, an enzyme involved in bone resorption.

Appearance :
Crystalline powder
Physical State :
Solid
Storage :
Store at -20° C
Boiling Point :
626.6-736.6° C at 760 mmHg (Predicted)
Density :
1.4±0.1 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10152654
SMILES :
CC(C)(C[C@@H](C(=O)NC1(CC1)C#N)N[C@@H](C2=CC=C(C=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(F)(F)F)F

Download SDS (MSDS)

Certificate of Analysis

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Hi, I am going to use this drug to inhibit Cathepsin K in my cell of interest. Could you tell me how to make (reconstitute) stock soln? Is this soluble in water? or, DMSO? MeOH? Thank you for your help!

Asked by: Tatapi
Thank you for your question. Odanacatib (CAS 603139-19-1) sc-364675 is reported to be soluble in DMSO and slightly in Chloroform and Methanol. Sonication may be needed for the latter two solvents and solutions should be prepared fresh. Stock solutions in DMSO may be stored at +4 °C for short term storage or at -20 °C for long term storage. For further information, please contact our technical service directly.
Answered by: Technical Support Europe
Date published: 2019-04-05
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Rated 5 out of 5 by from Schultz et al Schultz et al. (PubMed ID 26344800) found that Odanacatib inhibited cathepsin K and reduced bone absorption while also preserving bone formation in women with postmenopausal osteoporosis. -SCBT Publication Review
Date published: 2015-05-27
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