Octopamine HydrochlorideAn activator of β3-AR and α2A-AR adrenoceptors

Octopamine Hydrochloride (CAS 770-05-8)

Octopamine Hydrochloride | CAS 770-05-8 is rated 5.0 out of 5 by 1.
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Synonym: Epirenor; Norden; Norfen; Norphen
Application: An activator of β3-AR and α2A-AR adrenoceptors
CAS Number: 770-05-8
Purity: ≥97%
Molecular Weight: 189.64
Molecular Formula: C8H11NO2 HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Octopamine hydrochloride is an invertebrate biogenic amine neurotransmitter, related to noradrenalin, that is an adrenoceptor (AR) agonist. Octopamine hydrochloride stimulates lipolysis in mammalian adipocytes via activation of β3-AR receptors. Has dual effect on glucose transport in adipocytes: inhibits transport via β3-AR receptor activation but stimulates transport when oxidised by MAO. Also activates human α2A-AR receptors, inhibiting subsequent cAMP production.


References

1. Airriess, C.N., et al. 1997. Br. J. Pharmacol. 122: 191-198. PMID: 9313925
2. Roeder, T. 1999. Prog. Neurobiol. 59: 533-561. PMID: 10515667
3. Carpene, C., et al. 1999. Naunyn-Schmied. Arch. Pharmacol. 359: 310-321. PMID: 10344530
4. Visentin, V., et al. 2001. J. Pharmacol. Exp. Ther. 299: 96-104. PMID: 11561068

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (38 mg/ml at 25° C), DMSO (38 mg/ml at 25° C), ethanol (11 mg/ml at 25° C), and methanol.
Storage :
Store at room temperature
Melting Point :
~170° C (lit.)(dec.)
Boiling Point :
360.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
102484
Merck Index :
14: 6759
MDL Number :
MFCD00012881
EC Number :
212-216-4
Beilstein Registry :
3915414
SMILES :
C1=CC(=CC=C1C(CN)O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Does octopamine hydrochloride come from octopus?

Asked by: Shie
Thank you for your question. This compound is derived from a synthetic source.
Answered by: Technical Support
Date published: 2017-10-02
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Rated 5 out of 5 by from Octopamine Hydrochloride was reported as Octopamine Hydrochloride was reported as an adreno receptor agonist in many articles. -SCBT Publication Review
Date published: 2015-04-13
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