Obatoclax MesylateA novel Bcl-2 homology domain-3 (BH3) mimetic

Obatoclax Mesylate (CAS 803712-79-0)

Obatoclax Mesylate | CAS 803712-79-0 is rated 5.0 out of 5 by 1.
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Synonym: GX15-070; 2-[(5Z)-5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-yl]-1H-indole mesylate
Application: A novel Bcl-2 homology domain-3 (BH3) mimetic
CAS Number: 803712-79-0
Purity: ≥98%
Molecular Weight: 413.49
Molecular Formula: C20H19N3O• CH4O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Obatoclax Mesylate is an inhibitor of Bcl-2, a novel Bcl-2 homology domain-3 (BH3) mimetic.

Physical State :
Solid
Solubility :
Soluble in DMSO (83 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (~2 mg/ml), and DMF (~5 mg/ml).
Storage :
Store at -20° C
Melting Point :
228-233° C
Refractive Index :
n20D ~1.65 (Predicted)
IC50 :
KARPAS-45: IC50 = 0.03 nM (human); SK-MEL-30: IC50 = 0.36 nM (human); NALM-6: IC50 = 0.36 nM (human); KYSE-450: IC50 = 0.47 nM (human); BHY: IC50 = 0.60 nM (human)
Ki Data :
Bcl-2: Ki= 220 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46930996
MDL Number :
MFCD18074508
SMILES :
CC1=CC(=C(N1)/C=C\2/C(=C/C(=C\3/C=C4C=CC=CC4=N3)/N2)OC)C.CS(=O)(=O)O

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Certificate of Analysis

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Rated 5 out of 5 by from Noelker et al Noelker et al. (PubMed ID 26104567) found that inhibition of GCase activity with conduritol-B-epoxide (CBE) enhances both -Syn and MPP induced toxicity in dopaminergic neurons. -SCBT Publication Review
Date published: 2015-02-11
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