Anti-OATP-A Antibody (E-7) is a mouse monoclonal IgG2b κ OATP-A antibody, cited in 1 publications, provided at 200 µg/ml
raised against amino acids 611-665 mapping near the C-terminus of OATP-A of human origin
OATP-A Antibody (E-7) is recommended for detection of OATP-A of human origin by WB, IP, IF and ELISA
Anti-OATP-A Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of OATP-A (E-7): sc-365007.
m-IgG2b BP-HRP is the preferred secondary detection reagent for OATP-A Antibody (E-7) for WB applications. This reagent is now offered in a bundle with OATP-A Antibody (E-7) (see ordering information below).
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OATP-A Antibody (E-7) is a high quality monoclonal OATP-A antibody (also designated OATP-A antibody) suitable for the detection of the OATP-A protein of human origin. OATP-A Antibody (E-7) is available as both the non-conjugated anti-OATP-A antibody form, as well as multiple conjugated forms of anti-OATP-A antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The organic anion transporting polypeptides, OATP-A (also designated OATP1, OATP1A2 and SLC21A3) and OATP-C (also designated OATP2, SLC21A6 and LST1), mediate hepatic uptake of cardiac glycosides. The expression of OATP-C, but not OATP-A, is inducible by phenobarbital and pregnenolone-16a-carbonitrile, resulting in the increased capacity of the liver to extract cardiac glycosides from the plasma. OATP-A is expressed in liver and kidney and helps mediate sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate, estradiol-17-glucuronide and prostaglandin. OATP-C is exclusively expressed in liver and is localized to the basolateral hepatocyte membrane. Although OATP-C mRNA levels decrease during pregnancy and increase postpartum, OATP-C protein levels remain relatively constant. OATP-C transports taurocholic acid, the adrenal androgen dehydroepiandroserone sulfate, thyroid hormone, hydroxymethylglutaryl-CoA reductase inhibitor and pravastatin. OATP-C is therefore a novel organic anion transport protein that has overlapping but not identical substrate specificities with other subtypes of OATP. OATP-A and OATP-C are both pravastatin transporters, suggesting that they are responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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